| 20.08.2021 (19:00): FC MIDTJYLLAND - SILKEBORG | |
| | 5. | 1-0 | Evander Ferreira, straffe | Mads-Kristoffer Kristoffersen | | | 45. | 2-0 | Pione Sisto | | | | 62. | 3-0 | Anders Dreyer | | | |
| | Elias Olafsson | Nicolai Larsen | | | Henrik Dalsgaard | Rasmus Carstensen | | | Erik Sviatchenko | Tobias Salquist | | | Paulinho  (72) | André Calisir  (17) / (79) | | | Joel Andersson | Gustav Dahl (4) | | | Raphael Onyedika (72) | Stefan Teitur Thordarson (84) | | | Evander Ferreira  (5) | Mark Brink | | | Nikolas Dyhr (84) | Anders Klynge (84) | | | Gustav Isaksen (84) | Sebastian Jørgensen (79) | | | Anders Dreyer (62) | Nicolai Vallys | | | Pione Sisto (45) / (59) | Nicklas Helenius | | |
| | | Daniel Høegh | Joel Felix  (79) | | | Awer Mabil (59) | Oliver Sonne | | | Jared Thompson | Pelle Mattsson | | | Mikael Anderson (72) | Alexander Lind (79) | | | Charles (84) | Stan van Bladeren | | | Nicolas Madsen (72) | Nicklas Røjkjær (84) | | | Victor Lind (84) | Andreas Oggesen (84) | | |
| 21.08.2021 (18:00): OB - BRØNDBY | |
| | 4. | 0-1 | Mikael Uhre | Jørgen Daugbjerg Burchardt | | | 43. | 0-2 | Mikael Uhre | | | | 55. | 1-2 | Emmanuel Sabbi | | | | 84. | 2-2 | Mart Lieder | | | |
| | Oliver Christensen | Mads Hermansen | | | Robin Østrøm | Anton Skipper (46) | | | Jeppe Tverskov | Andreas Maxsø | | | Alexander Juel Andersen | Kevin Tshiembe (70) | | | Jørgen Skjelvik | Andreas Bruus (67) | | | Jens Jakob Thomasen (72) | Morten Frendrup | | | Aron Elis Thrandarson (83) | Josip Radosevic (72) | | | Emmanuel Sabbi (55) / (90) | Anis Ben Slimane | | | Issam Jebali (83) | Kevin Mensah | | | Troels Kløve | Mikael Uhre (4,43) | | | Bashkim Kadrii (72) | Simon Hedlund (72) | | |
| | | Mart Lieder (72) / (84) | Jens Martin Gammelby (46) | | | Hans Christian Bernat | Rezan Corlu | | | Max Fenger (83) | Andrija Pavlovic (72) | | | Ayo Okosun (83) | Oskar Fallenius | | | Tarik Ibrahimagic | Rasmus Wikström | | | Moses Opondo (90) | Andreas Pyndt (72) | | | Mads Frøkjær-Jensen (72) | Jonathan Ægidius | | |
| 22.08.2021 (14:00): RANDERS FC - AAB | |
| | 19. | 0-1 | Milan Makaric | Mikkel Redder | | | 24. | 1-1 | Vito Hammershøy-Mistrati, straffe | | | |
| | Patrik Carlgren (89) | Jacob Rinne | | | Mikkel Kallesøe (74) / (80) | Mathias Ross | | | Simon Piesinger (38) | Rasmus Thelander (88) | | | Erik Marxen | Daniel Granli (46) | | | Björn Kopplin (90) | Kristoffer Pallesen (85) | | | Tosin Kehinde (80) | Malthe Højholt (46) | | | Lasse Berg Johnsen | Pedro Ferreira (55) | | | Vincent Onovo (52) | Frederik Børsting (33) | | | Jakob Ankersen (61) | Louka Prip | | | Vito Hammershøy-Mistrati (24) | Iver Fossum | | | Marvin Egho (61) | Milan Makaric (19) / (76) | | |
| | | Simon Tibbling (80) / (81) | Jakob Ahlmann (33) / (41) | | | Frederik Lauenborg (52) | Tim Prica (76) | | | Jesper Lauridsen (80) | Anders Hagelskjær (46) | | | Tobias Klysner (61) | Magnus Christensen | | | Oliver Bundgaard | Kasper Kusk (46) | | | Jonas Dakir | Andreas Hansen | | | Alhaji Kamara (61) / (90) | Marcus Hannesbo (85) | | |
| 22.08.2021 (16:00): FC KØBENHAVN - SØNDERJYSKE | |
| | 50. | 1-0 | Pep Biel | Peter Kjærsgaard | | | 72. | 2-0 | Jonas Wind | | | |
| | Kamil Grabara | Lawrence Thomas | | | Peter Ankersen (62) | Emil Holm | | | David Khocholava | Stefan Gartenmann | | | Nicolai Boilesen | Duplexe Tchamba | | | Victor Kristiansen | Marc Dal Hende | | | Rasmus Falk | Mads Albæk | | | Carlos Zeca (66) | Emil Kornvig (46) | | | William Bøving (62) | Victor Ekani (89) | | | Pep Biel (50) / (80) | Rilwan Hassan (29) / (79) | | | Mohamed Daramy (80) | Anders K. Jacobsen (15) | | | Jonas Wind (72) / (90) | Isak Steiner Jensen (46) | | |
| | | Kevin Diks (62) | Pierre Kanstrup (79) | | | Jens Stage (62) | Kristofer Kristinsson (89) | | | Luther Singh (80) | Jeppe Simonsen (46) | | | Karl-Johan Johnsson | Emil Frederiksen | | | Marios Oikonomou | Rasmus Vinderslev (46) | | | Rasmus Højlund (80) | Andulrahman Taiwo (15) | | | Hakon Arnar Haraldsson (90) | Nicolai Flø | | |
| 22.08.2021 (18:00): VIBORG - AGF | |
| | 16. | 1-0 | Jakob Bonde, straffe | Michael Tykgaard | | | 26. | 2-0 | Ibrahim Said | | | |
| | Lucas Lund Pedersen | Jesper Hansen | | | Frans Putros (78) / (84) | Alexander Munksgaard (85) | | | Lars Kramer | Yann Aurel Bisseck (15) | | | Mads Lauritsen | Frederik Tingager (84) | | | Christian Sørensen (25) | Eric Kahl | | | Justin Lonwijk (58) / (84) | Anthony D'Alberto (46) | | | Jeppe Grønning | Nicolai Poulsen (84) | | | Jakob Bonde (16) / (79) | Zachary Duncan (46) | | | Tobias Bech (59) / (79) | Patrick Olsen | | | Sebastian Grønning | Patrick Mortensen | | | Ibrahim Said (26) / (66) | Jon Thorsteinsson | | |
| | | Jeff Mensah (66) | Søren Tengstedt (85) / (90) | | | Jay-Roy Grot (79) | Oliver Lund (84) | | | Clint Leemans (79) | Jesper Juelsgård (84) | | | Kelian van der Kaap | Albert Grønbæk (46) | | | Sofus Berger (85) | Frederik Brandhof (46) | | | Daniel Anyembe (84) | Daniel Gadegaard Andersen | | | Can Dursun | Alexander Ammitzbøll | | |
| 23.08.2021 (19:00): FC NORDSJÆLLAND - VEJLE | |
| | 3. | 1-0 | Andreas Schjelderup | Anders Poulsen | | | 20. | 2-0 | Andreas Schjelderup, straffe | | | | 59. | 2-1 | Wahid Faghir | | | | 90. | 3-1 | Oliver Antman | | | |
| | Peter Vindahl Jensen | Alexander Brunst | | | Mads Døhr Tychosen | Manjrekar James (66) | | | Kian Hansen (79) | Denis Kolinger | | | Adamo Nagalo | Jerome Opoku (85) | | | Oliver Villadsen | Kevin Custovic (68) | | | Abu Francis (65) | Saeid Ezatolahi (68) | | | Magnus Kofod Andersen | Hans Høllsberg | | | Daniel Svensson (74) | Lukas Engel | | | Mohamed Diomande (74) | Arbnor Mucolli (21) / (74) | | | Lasso Coulibaly (74) | Allan Sousa | | | Andreas Schjelderup (3,20) | Wahid Faghir (59) | | |
| | | Maxwell Woledzi (79) | Viljormur Davidsen (74) | | | Martin Frese (74) | Mads Greve | | | Jacob Christensen | Aleksei Chernov | | | Simon Adingra (74) | Dimitrios Emmanouilidis (85) | | | Oliver Antman (74) / (90) | Lundrim Hetemi (68) | | | Andreas Gülstorff | Kevin Yamga (68) | | | Leo Walta (65) | | | |
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