| 26.09.2021 (14:00): FC MIDTJYLLAND - RANDERS FC | |
| | 17. | 1-0 | Erik Sviatchenko | Jørgen Daugbjerg Burchardt | | |
| | Elias Olafsson | Patrik Carlgren | | | Henrik Dalsgaard | Mikkel Kallesøe  (46) | | | Erik Sviatchenko  (17) / (46) | Simon Graves (82) | | | Juninho | Erik Marxen | | | Joel Andersson | Oliver Bundgaard | | | Raphael Onyedika  (82) | Tosin Kehinde (26) / (74) | | | Charles (72) | Lasse Berg Johnsen | | | Paulinho | Frederik Lauenborg (31) / (61) | | | Gustav Isaksen (60) | Simon Tibbling (45) / (61) | | | Junior Brumado (66) / (81) | Vito Hammershøy-Mistrati | | | Pione Sisto (60) | Alhaji Kamara | | |
| | | Dion Cools | Simon Piesinger  (82) | | | Daniel Høegh (46) | Jakob Ankersen (61) | | | Awer Mabil (60) | Björn Kopplin (46) | | | Oliver Sørensen (72) | Tobias Klysner (74) | | | Jared Thompson | Mathias Greve | | | Marrony (81) | Vincent Onovo | | | Victor Lind (60) | Stephen Odey (61) | | |
| 26.09.2021 (14:00): VIBORG - OB | |
| | 7. | 1-0 | Justin Lonwijk | Jakob Kehlet | | | 62. | 1-1 | Emmanuel Sabbi | | | |
| | Lucas Lund Pedersen | Hans Christian Bernat | | | Frans Putros | Nicholas Mickelson (63) | | | Mads Lauritsen | Kasper Larsen (26) | | | Lorenzo Gordinho | Jeppe Tverskov | | | Christian Sørensen | Jørgen Skjelvik | | | Justin Lonwijk (7) / (90) | Troels Kløve (20) / (58) | | | Jeppe Grønning | Aron Elis Thrandarson | | | Jakob Bonde (87) | Emmanuel Sabbi (28) / (62) | | | Tobias Bech (63) | Mads Frøkjær-Jensen (63) | | | Sebastian Grønning (75) | Max Fenger (58) | | | Jay-Roy Grot (74) | Bashkim Kadrii | | |
| | | Alassana Jatta (75) | Alexander Juel Andersen (26) | | | Clint Leemans (87) | Mart Lieder (58) | | | Mikkel Andersen | Jens Jakob Thomasen (58) | | | Kelian van der Kaap | Tarik Ibrahimagic | | | Sofus Berger | Robin Østrøm (63) | | | Younes Bakiz (63) | Sayouba Mandé | | | Ibrahim Said (75) | Jakob Breum (63) | | |
| 26.09.2021 (16:00): FC NORDSJÆLLAND - FC KØBENHAVN | |
| | 19. | 0-1 | Jens Stage | Mads-Kristoffer Kristoffersen | | | 49. | 0-2 | Selvmål, Mads Døhr Tychosen | | | | 52. | 1-2 | Adamo Nagalo | | | | 57. | 1-3 | Kevin Diks | | | | 64. | 1-4 | Pep Biel | | | | 80. | 1-5 | Isak Bergmann Johannesson | | | |
| FC NORDSJÆLLAND | FC KØBENHAVN | |
| | Emmanuel Ogura | Kamil Grabara | | | Mads Døhr Tychosen  (49) | Kevin Diks (57) / (90) | | | Kian Hansen (25) | David Khocholava (84) | | | Adamo Nagalo (52) / (76) | Nicolai Boilesen | | | Oliver Villadsen | Victor Kristiansen | | | Simon Adingra (66) | Carlos Zeca (74) | | | Magnus Kofod Andersen | Lukas Lerager (39) / (77) | | | Martin Frese | Jens Stage (19) | | | Mohamed Diomande | Pep Biel (64) | | | Lasso Coulibaly (76) | William Bøving (82) | | | Andreas Schjelderup (76) | Jonas Wind (82) | | |
| | | Maxwell Woledzi (25) | Ruben Gabrielsen (84) | | | Jacob Christensen (76) | Luther Singh (82) | | | Ibrahim Sadiq (66) | Isak Bergmann Johannesson (77) / (80) | | | Abu Francis (76) | Kamil Wilczek | | | Emmanuel Ogura | Karl-Johan Johnsson | | | Daniel Svensson (76) | Peter Ankersen | | | Leo Walta | Rasmus Højlund (82) | | |
| 26.09.2021 (18:00): BRØNDBY - AAB | |
| | 27. | 0-1 | Louka Prip | Michael Tykgaard | | | 49. | 1-1 | Mikael Uhre | | | | 76. | 2-1 | Mikael Uhre | | | |
| | Mads Hermansen | Jacob Rinne | | | Sigurd Rosted | Mathias Ross (82) | | | Andreas Maxsø | Rasmus Thelander | | | Kevin Tshiembe | Daniel Granli (59) | | | Andreas Bruus | Kristoffer Pallesen (90) | | | Anis Ben Slimane (73) | Malthe Højholt | | | Josip Radosevic | Pedro Ferreira (55) | | | Morten Frendrup (46) | Frederik Børsting (82) | | | Kevin Mensah (76) | Iver Fossum | | | Mikael Uhre (49,76) / (82) | Louka Prip (27) / (59) | | | Simon Hedlund (82) | Milan Makaric (10) | | |
| | | Mathias Greve (46) | Aleksandar Trajkovski (59) | | | Andrija Pavlovic (82) | Tim Prica (10) | | | Thomas Mikkelsen | Anders Hagelskjær (59) | | | Christian Cappis (73) | Magnus Christensen | | | Marko Divkovic | Kasper Kusk (82) | | | Jagvir Singh Sidhu (82) | Andreas Hansen | | | Tobias Børkeeiet | Marcus Hannesbo (82) | | |
| 26.09.2021 (20:00): VEJLE - SILKEBORG | |
| | 17. | 1-0 | Dimitrios Emmanouilidis | Mikkel Redder | | | 26. | 1-1 | Sebastian Jørgensen | | | | 30. | 1-2 | Sebastian Jørgensen | | | | 33. | 2-2 | Lukas Engel | | | | 37. | 2-3 | Nicklas Helenius, straffe | | | | 78. | 2-4 | Nicolai Vallys | | | |
| | Sten Grytebust | Nicolai Larsen | | | Tobias Mølgaard (81) | Rasmus Carstensen | | | Manjrekar James | Tobias Salquist | | | Jerome Opoku (83) | André Calisir (32) | | | Viljormur Davidsen | Gustav Dahl | | | Allan Sousa (90) | Stefan Teitur Thordarson | | | Mouhamadou Drammeh | Mark Brink | | | Hans Høllsberg (59) | Robert Gojani (88) | | | Lukas Engel (33) / (73) | Sebastian Jørgensen (26,30) / (73) | | | Dimitrios Emmanoulidis (17) / (59) | Nicklas Helenius (37) / (88) | | | Andrés Ponce (46) | Nicolai Vallys (78) | | |
| | | Alexander Brunst | Joel Felix (32) | | | Saeid Ezatolahi (59) / (75) | Oliver Sonne | | | Kevin Custovic (83) | Pelle Mattsson (88) | | | Jacob Schoop (46) | Søren Tengstedt (88) | | | Brandon Pierrick (73) | Stan van Bladeren | | | Lundrim Hetemi | Anders Klynge (73) | | | Kevin Yamga (59) | | | |
| 27.09.2021 (19:00): AGF - SØNDERJYSKE | |
| | 35. | 1-0 | Jon Thorsteinsson | Jonas Hansen | | |
| | Jesper Hansen | Lawrence Thomas | | | Oliver Lund | Emil Holm | | | Sebastian Hausner (87) | Stefan Gartenmann | | | Yann Aurel Bisseck (84) | Søren Reese (54) | | | Eric Kahl | Marc Dal Hende (10) | | | Albert Grønbæk (56) | Mads Albæk | | | Nicolai Poulsen (30) / (87) | Victor Ekani (61) | | | Mikael Anderson (50) / (65) | Emil Kornvig (82) | | | Mustapha Bundu (65) | Daniel Prosser (82) | | | Patrick Mortensen | Abdulrahman Taiwo | | | Jon Thorsteinsson (35) / (72) | Julius Eskesen (73) | | |
| | | Frederik Tingager (87) | Faris Moumbagna (82) | | | Patrick Olsen (65) | Maxime Soulas | | | Jesper Juelsgård (87) | Kristofer Kristinsson (73) / (90) | | | Dawid Kurminowski | Jeppe Simonsen (82) | | | Anthony D'Alberto | Rasmus Vinderslev (61) | | | Frederik Brandhof (65) | Nicolai Flø | | | Daniel Gadegaard Andersen | Rilwan Hassan | | |
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