| 01.10.2021 (19:00): OB - VEJLE | |
| | 2. | 1-0 | Max Fenger | Jørgen Daugbjerg Burchardt | | | 5. | 2-0 | Mads Frøkjær-Jensen | | | | 8. | 3-0 | Jens Jakob Thomasen | | | | 25. | 4-0 | Mads Frøkjær-Jensen | | | | 79. | 5-0 | Troels Kløve | | | | 82. | 6-0 | Jakob Breum | | | |
| | Hans Christian Bernat | Sten Grytebust | | | Nicholas Mickelson  (72) | Tobias Mølgaard | | | Jeppe Tverskov | Manjrekar James  (70) | | | Alexander Juel Andersen | Denis Kolinger (88) | | | Robin Østrøm | Viljormur Davidsen (78) | | | Jens Jakob Thomasen  (8) / (81) | Allan Sousa | | | Aron Elis Thrandarson | Hans Høllsberg (46) | | | Emmanuel Sabbi (67) / (72) | Mouhamadou Drammeh | | | Mads Frøkjær-Jensen (5,25) / (47) / (81) | Arbnor Mucolli (85) | | | Max Fenger (2) | Saeid Ezatolahi (39) | | | Bashkim Kadrii (72) | Lukas Engel (46) | | |
| | | Mart Lieder  (72) | Alexander Brunst | | | Mathias Brems (72) | Heron (78) | | | Ayo Okosun | Jerome Opoku | | | Tarik Ibrahimagic (81) | Andrés Ponce (46) | | | Troels Kløve (72) / (79) | Dimitrios Emmanoulidis (46) | | | Sayouba Mandé | Lundrim Hetemi (85) | | | Jakob Breum (81) | Kevin Yamga | | |
| 03.10.2021 (14:00): AAB - SØNDERJYSKE | |
| | 10. | 1-0 | Iver Fossum | Jakob Kehlet | | | 41. | 2-0 | Milan Makaric | | | | 53. | 3-0 | Louka Prip | | | | 57. | 4-0 | Iver Fossum | | | |
| | Jacob Rinne | Lawrence Thomas | | | Daniel Granli | Emil Holm (21) / (59) | | | Rasmus Thelander | Stefan Gartenmann | | | Anders Hagelskjær (78) | Søren Reese (46) | | | Kristoffer Pallesen | Duplexe Tchamba | | | Malthe Højholt | Marc Dal Hende (84) | | | Magnus Christensen (25) / (46) | Mads Albæk (85) | | | Frederik Børsting (46) | Victor Ekani | | | Iver Fossum (10,57) | Emil Kornvig (46) | | | Aleksandar Trajkovski (66) | Abdulrahman Taiwo | | | Milan Makaric (41) / (78) | Daniel Prosser (63) | | |
| | | Jakob Ahlmann (46) | Julius Eskesen | | | Mathias Ross | Faris Moumbagna (46) | | | Tim Prica (78) | Jeppe Simonsen (59) | | | Kasper Kusk (66) | Rasmus Vinderslev (63) | | | Louka Prip (53) / (46) | Nicolai Flø | | | Andreas Hansen | Isak Steiner Jensen (46) | | | Marcus Hannesbo (78) | Rilwan Hassan | | |
| 03.10.2021 (16:00): SILKEBORG - FC NORDSJÆLLAND | |
| | 1. | 1-0 | Nicklas Helenius | Anders Poulsen | | | 8. | 2-0 | Nicklas Helenius | | | | 23. | 2-1 | Oliver Villadsen | | | | 69. | 3-1 | Stefan Teitur Thordarson | | | | 87. | 4-1 | Sebastian Jørgensen | | | |
| | Nicolai Larsen | Eduardo dos Santos Haesler | | | Rasmus Carstensen | Adamo Nagalo (64) | | | Tobias Salquist (39) | Maxwell Woledzi (85) | | | André Calisir (34) | Daniel Svensson | | | Gustav Dahl (32) | Oliver Villadsen (23) | | | Stefan Teitur Thordarson (69) / (83) | Abu Francis | | | Mark Brink (60) | Magnus Kofod Andersen | | | Robert Gojani | Mohamed Diomande (59) / (64) | | | Sebastian Jørgensen (87) | Martin Frese (80) | | | Nicklas Helenius (1,8) / (83) | Lasso Coulibaly (64) | | | Nicolai Vallys | Ibrahim Sadiq (80) | | |
| | | Joel Felix (34) | Mads Døhr Tychosen (64) | | | Oliver Sonne | Jacob Christensen (64) / (67) | | | Søren Tengstedt (83) | Andreas Schjelderup (64) | | | Stan van Bladeren | Emmanuel Ogura | | | Anders Klynge (60) | Simon Adingra (80) | | | Nicklas Røjkjær (83) | Andreas Bredahl (80) | | | Frederik Carstensen | Oliver Antman | | |
| 03.10.2021 (16:00): FC MIDTJYLLAND - AGF | |
| | 4. | 1-0 | Junior Brumado | Sandi Putros | | | 19. | 2-0 | Junior Brumado, straffe | | | | 27. | 3-0 | Paulinho | | | | 31. | 4-0 | Junior Brumado | | | |
| | Elias Olafsson | Jesper Hansen | | | Henrik Dalsgaard | Oliver Lund (79) | | | Erik Sviatchenko (71) | Sebastian Hausner (19) | | | Juninho (79) | Yann Aurel Bisseck (56) | | | Joel Andersson | Eric Kahl | | | Raphael Onyedika | Nicolai Poulsen (56) | | | Jens-Lys Cajuste | Mustapha Bundu | | | Paulinho (27) / (64) / (71) | Albert Grønbæk (46) | | | Gustav Isaksen (60) | Mikael Anderson | | | Junior Brumado (4,19,31) / (79) | Patrick Olsen | | | Pione Sisto | Patrick Mortensen (71) | | |
| | | Jonas Lössl | Frederik Tingager (56) | | | Dion Cools (79) | Jesper Juelsgård | | | Daniel Høegh (71) | Zachary Duncan (56) | | | Charles | Dawid Kurminowski (71) | | | Marrony (60) | Anthony D'Alberto (79) | | | Nikolas Dyhr (71) | Frederik Brandhof (46) | | | Victor Lind (79) | Daniel Gadegaard Andersen | | |
| 03.10.2021 (18:00): RANDERS FC - BRØNDBY | |
| | 10. | 1-0 | Stephen Odey | Jens Maae | | | 40. | 1-1 | Selvmål, Simon Graves | | | |
| | Patrik Carlgren | Mads Hermansen | | | Mikkel Kallesøe (79) | Sigurd Rosted | | | Simon Piesinger | Andreas Maxsø (57) | | | Simon Graves  (40) | Kevin Tshiembe (90) | | | Björn Kopplin | Andreas Bruus | | | Simon Tibbling (46) | Anis Ben Slimane | | | Lasse Berg Johnsen | Josip Radosevic (72) | | | Frederik Lauenborg (46) | Morten Frendrup | | | Tobias Klysner | Kevin Mensah | | | Vito Hammershøy-Mistrati (65) | Mikael Uhre (59) | | | Stephen Odey (10) / (72) | Simon Hedlund (72) | | |
| | | Jakob Ankersen (79) | Jens Martin Gammelby | | | Tosin Kehinde (46) | Henrik Heggheim | | | Jesper Lauridsen | Mathias Greve (72) | | | Oliver Bundgaard (46) | Thomas Mikkelsen | | | Jonas Dakir | Christian Cappis (72) | | | Vincent Onovo (65) | Marko Divkovic (59) | | | Alhaji Kamara (72) / (77) | Jagvir Singh Sidhu | | |
| 03.10.2021 (20:00): FC KØBENHAVN - VIBORG | |
| | 77. | 1-0 | Jens Stage | Morten Krogh | | | 90. | 1-1 | Selvmål, Jens Stage | | | |
| | Kamil Grabara | Lucas Lund Pedersen | | | Kevin Diks (2) | Frans Putros | | | David Khocholava (61) | Lars Kramer | | | Nicolai Boilesen | Mads Lauritsen | | | Victor Kristiansen | Christian Sørensen | | | Carlos Zeca (82) | Tobias Bech (56) | | | Lukas Lerager (65) | Justin Lonwijk (87) | | | Jens Stage (77) / (90) | Jeppe Grønning | | | Pep Biel | Jakob Bonde (87) | | | William Bøving (65) | Younes Bakiz (72) | | | Jonas Wind | Jay-Roy Grot (72) | | |
| | | Ruben Gabrielsen | Lorenzo Gordinho | | | Luther Singh | Sebastian Grønning (72) | | | Isak Bergmann Johannesson (65) | Alassana Jatta (87) | | | Karl-Johan Johnsson | Clint Leemans (87) | | | Peter Ankersen (82) | Mikkel Andersen | | | Rasmus Højlund (65) | Sofus Berger (72) | | | Hakon Arnar Haraldsson | Ibrahim Said (56) | | |
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