| 15.10.2021 (19:00): VIBORG - SILKEBORG | |
| | 64. | 0-1 | Stefan Teitur Thordarson | Peter Kjærsgaard | | | 66. | 1-1 | Sebastian Grønning | | | |
| | Mikkel Andersen | Nicolai Larsen | | | Frans Putros | Rasmus Carstensen | | | Lars Kramer | Tobias Salquist | | | Mads Lauritsen | Joel Felix | | | Christian Sørensen | Nicklas Røjkjær | | | Justin Lonwijk | Stefan Teitur Thordarson  (64) | | | Jeppe Grønning  (57) | Mark Brink (79) | | | Jakob Bonde | Robert Gojani | | | Jay-Roy Grot (57) | Sebastian Jørgensen | | | Sebastian Grønning (66) | Nicolai Vallys | | | Tobias Bech (57) | Nicklas Helenius | | |
| | | Lorenzo Gordinho | Pelle Mattsson  (79) | | | Alassana Jatta | Stan van Bladeren | | | Clint Leemans (57) | Gustav Marcussen | | | Sofus Berger | Anders Klynge | | | Younes Bakiz (57) | Andreas Oggesen | | | Ibrahim Said (57) | Alexander Busch | | | | Frederik Carstensen | | |
| 17.10.2021 (13:00): FC NORDSJÆLLAND - FC MIDTJYLLAND | |
| | 14. | 1-0 | Simon Adingra | Jens Maae | | | 28. | 2-0 | Mads Døhr Tychosen | | | | 48. | 2-1 | Junior Brumado | | | | 62. | 2-2 | Victor Lind | | | |
| FC NORDSJÆLLAND | FC MIDTJYLLAND | |
| | Emmanuel Ogura | Elias Olafsson | | | Mads Døhr Tychosen (28) | Henrik Dalsgaard | | | Maxwell Woledzi  (81) | Erik Sviatchenko | | | Adamo Nagalo (69) | Dion Cools (46) | | | Oliver Villadsen (69) | Joel Andersson | | | Mohamed Diomande (38) | Jens-Lys Cajuste (46) | | | Magnus Kofod Andersen | Evander Ferreira | | | Abu Francis (86) | Paulinho | | | Simon Adingra (14) | Gustav Isaksen (46) | | | Andreas Bredahl (69) | Junior Brumado (44) / (48) / (59) | | | Lasso Coulibaly | Pione Sisto | | |
| | | Eduardo dos Santos Haesler | Jonas Lössl | | | Martin Frese (38) | Daniel Høegh | | | Jacob Christensen (69) | Charles | | | Oliver Antman (86) | Raphael Onyedika (46) / (77) | | | Daniel Svensson | Marrony (46) | | | Jonas Jensen-Abbew (69) | Nikolas Dyhr (46) | | | William Kumado (69) | Victor Lind (59) / (62) | | |
| 17.10.2021 (14:00): OB - RANDERS FC | |
| | 18. | 1-0 | Mads-Frøkjær-Jensen | Anders Poulsen | | | 56. | 1-1 | Stephen Odey | | | | 83. | 1-2 | Vito Hammershøy-Mistrati | | | |
| | Hans Christian Bernat | Patrik Carlgren | | | Nicholas Mickelson | Mikkel Kallesøe | | | Jeppe Tverskov | Simon Piesinger | | | Alexander Juel Andersen | Simon Graves (33) | | | Jørgen Skjelvik | Oliver Bundgaard (46) | | | Jens Jakob Thomasen (77) | Tobias Klysner (46) | | | Aron Elis Thrandarson | Lasse Berg Johnsen | | | Moses Opondo (62) | Vito Hammershøy-Mistrati (83) | | | Mads Frøkjær-Jensen (18) | Jakob Ankersen (79) | | | Max Fenger (88) | Stephen Odey (56) | | | Bashkim Kadrii (32) / (77) | Tosin Kehinde (87) | | |
| | | Kasper Larsen | Erik Marxen (33) | | | Mart Lieder (77) | Simon Tibbling (79) | | | Ayo Okosun (77) | Björn Kopplin (46) | | | Troels Kløve (62) | Andreas Søndergaard | | | Robin Østrøm | Vincent Onovo (87) | | | Sayouba Mandé | Filip Bundgaard | | | Jakob Breum (88) | Nicolai Brock-Madsen (46) | | |
| 17.10.2021 (16:00): BRØNDBY - VEJLE | |
| | 26. | 0-1 | Allan Sousa, straffe | Mads-Kristoffer Kristoffersen | | | 31. | 1-1 | Andreas Bruus | | | | 57. | 1-2 | Lukas Engel | | | | 82. | 2-2 | Mikael Uhre | | | | 86. | 3-2 | Christian Cappis | | | |
| | Thomas Mikkelsen | Sten Grytebust | | | Sigurd Rosted (25) / (63) | Tobias Mølgaard | | | Andreas Maxsø | Manjrekar James (33) | | | Kevin Tshiembe | Denis Kolinger | | | Andreas Bruus (31) / (80) | Jerome Opoku (67) | | | Anis Ben Slimane (90) | Allan Sousa (26) / (90) | | | Josip Radosevic (80) | Jacob Schoop (84) | | | Marko Divkovic (63) | Mouhamadou Drammeh (73) | | | Kevin Mensah | Lukas Engel (57) / (70) | | | Mikael Uhre (82) | Hallur Hansson | | | Simon Hedlund (80) | Andrés Ponce (73) | | |
| | | Henrik Heggheim | Alexander Brunst | | | Andrija Pavlovic (63) | Heron (70) | | | Blas Riveros (80) | Kevin Custovic (84) | | | Morten Frendrup (80) | Luka Djordjevic (73) | | | Christian Cappis (63) / (86) | Hans Høllsberg (73) | | | Jagvir Singh Sidhu (80) | Lundrim Hetemi | | | Jonathan Ægidius | Adam Fofana | | |
| 17.10.2021 (18:00): SØNDERJYSKE - FC KØBENHAVN | |
| | 33. | 1-0 | Jeppe Simonsen | Jens Maae | | | 65. | 1-1 | Pep Biel | | | |
| | Lawrence Thomas | Kamil Grabara | | | Emil Holm | Peter Ankersen | | | Stefan Gartenmann | Ruben Gabrielsen | | | Duplexe Tchamba | Nicolai Boilesen (88) | | | Jeppe Simonsen (33) | Kevin Diks | | | Victor Ekani (88) | Isak Bergmann Johannesson (35) | | | Rilwan Hassan (71) | Lukas Lerager | | | Julius Eskesen (71) | Pep Biel (65) | | | Mads Albæk | Jonas Wind | | | Daniel Prosser (83) | William Bøving (79) | | | Abdulrahman Taiwo (83) | Rasmus Højlund (58) | | |
| | | Søren Reese (83) | Luther Singh (58) | | | Emil Kornvig | Andri Fannar Baldursson | | | Faris Moumbagna (83) / (84) | Karl-Johan Johnsson | | | Emil Frederiksen (71) | Marios Oikonomou | | | Rasmus Vinderslev (71) | Valdemar Lund Jensen | | | Nicolai Flø | Hakon Arnar Haraldsson | | | Isak Steiner Jensen | Elias Jelert (79) | | |
| 18.10.2021 (19:00): AGF - AAB | |
| | 45. | 1-0 | Frederik Brandhof | Jakob A. Sundberg | | |
| | Jesper Hansen | Jacob Rinne | | | Anthony D'Alberto | Mathias Ross (21) / (46) | | | Sebastian Hausner | Rasmus Thelander | | | Yann Aurel Bisseck | Daniel Granli (26) / (89) | | | Eric Kahl (81) | Kristoffer Pallesen (79) | | | Frederik Brandhof (45) / (90) | Malthe Højholt | | | Nicolai Poulsen (24) | Pedro Ferreira | | | Albert Grønbæk (81) | Jakob Ahlmann (46) | | | Mustapha Bundu (89) | Iver Fossum | | | Patrick Mortensen | Milan Makaric (60) | | | Jon Thorsteinsson (4) / (81) | Aleksandar Trajkovski | | |
| | | Frederik Tingager (81) | Tim Prica (60) | | | Patrick Olsen (81) | Anders Hagelskjær (46) | | | Gift Links (89) | Magnus Christensen | | | Oliver Lund (81) | Kasper Kusk (79) | | | Zachary Duncan | Louka Prip (46) | | | Dawid Kurminowski | Andreas Hansen | | | Daniel Gadegaard Andersen | Frederik Børsting (89) | | |
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