| 05.11.2021 (19:00): VIBORG - FC NORDSJÆLLAND | |
| | 12. | 1-0 | Jakob Bonde | Peter Kjærsgaard | | | 26. | 1-1 | Oliver Antman | | | | 28. | 1-2 | Simon Adingra | | | | 90. | 2-2 | Lars Kramer | | | |
| | Mikkel Andersen | Emmanuel Ogura  (12) | | | Frans Putros  (75) | Mads Døhr Tychosen | | | Lars Kramer (43) /  (90) | Jonas Jensen-Abbew (46) | | | Mads Lauritsen (48) | Maxwell Woledzi | | | Christian Sørensen | Oliver Villadsen | | | Clint Leemans (60) | Jacob Christensen | | | Jakob Bonde (12) | Magnus Kofod Andersen (68) | | | Justin Lonwijk (60) | Daniel Svensson (68) | | | Jay-Roy Grot (75) | Abu Francis | | | Sebastian Grønning (25) | Oliver Antman (26) / (90) | | | Younes Bakiz (87) | Simon Adingra (28) / (75) | | |
| | | Lucas Lund Pedersen | Eduardo dos Santos Haesler | | | Lorenzo Gordinho | Andreas Schjelderup | | | Alassana Jatta  (87) | Andreas Bredahl (90) | | | Jeppe Grønning (60) | Lasso Coulibaly (75) | | | Sofus Berger (75) | Leo Walta (68) | | | Ibrahim Said (75) | Lucas Lykkegaard (68) | | | Tobias Bech (60) | Adamo Nagalo (46) | | |
| 07.11.2021 (14:00): AAB - RANDERS FC | |
| | 1. | 1-0 | Milan Makaric | Jonas Hansen | | | 56. | 1-1 | Alhaji Kamara | | | |
| | Jacob Rinne | Patrik Carlgren | | | Mathias Ross | Björn Kopplin | | | Rasmus Thelander | Simon Piesinger (90) | | | Anders Hagelskjær | Erik Marxen | | | Kristoffer Pallesen | Oliver Bundgaard | | | Pedro Ferreira (90) | Simon Tibbling (82) | | | Malthe Højholt | Lasse Berg Johnsen (46) | | | Louka Prip (75) | Frederik Lauenborg | | | Iver Fossum | Tobias Klysner (46) | | | Kasper Kusk (90) | Stephen Odey (75) | | | Milan Makaric (1) / (83) | Nicolai Brock-Madsen (46) | | |
| | | Jakob Ahlmann (75) | Jakob Ankersen (82) | | | Aleksandar Trajkovski | Tosin Kehinde (46) | | | Tim Prica (83) | Jesper Lauridsen | | | Andreas Hansen | Vito Hammershøy-Mistrati (46) | | | Rufo (90) | Jonas Dakir | | | Casper Gedsted | Marvin Egho (75) | | | Marcus Hannesbo | Alhaji Kamara (46) / (56) / (87) | | |
| 07.11.2021 (14:00): VEJLE - SØNDERJYSKE | |
| | 34. | 1-0 | Arbnor Mucolli | Morten Krogh | | | 60. | 2-0 | Saeid Ezatolahi | | | | 63. | 3-0 | Selvmål, Duplexe Tchamba | | | | 90. | 3-1 | Emil Holm | | | |
| | Sten Grytebust | Nicolai Flø | | | Tobias Mølgaard | Jeppe Simonsen (36) / (75) | | | Manjrekar James (71) | Stefan Gartenmann | | | Denis Kolinger (90) | Duplexe Tchamba  (63) | | | Heron | Marc Dal Hende | | | Arbnor Mucolli (34) / (74) | Mads Albæk | | | Saeid Ezatolahi (60) / (84) | Victor Ekani | | | Hallur Hansson (78) | Julius Eskesen (69) | | | Lukas Engel (74) | Emil Holm (90) | | | Allan Sousa (84) | Abdulrahman Taiwo (57) | | | Andrés Ponce (62) | Rilwan Hassan (69) | | |
| | | Alexander Brunst | Lawrence Thomas | | | Viljormur Davidsen | Søren Reese (69) | | | Mouhamadou Drammeh (84) | Emil Kornvig (69) | | | Kevin Custovic (74) | Faris Moumbagna (57) | | | Luka Djordjevic (62) | Kristofer Kristinsson (75) | | | Dominic Vinicius (84) | Daniel Prosser | | | Lundrim Hetemi (74) | Mads Hansen | | |
| 07.11.2021 (16:00): AGF - FC MIDTJYLLAND | |
| | 16. | 1-0 | Patrick Mortensen | Aydin Uslu | | | 24. | 2-0 | Mikael Anderson | | | | 41. | 3-0 | Mustapha Bundu | | | |
| | Jesper Hansen | Elias Olafsson | | | Anthony D'Alberto | Henrik Dalsgaard | | | Sebastian Hausner (85) | Erik Sviatchenko | | | Frederik Tingager | Juninho (46) | | | Oliver Lund (29) | Joel Andersson (76) | | | Nicolai Poulsen | Raphael Onyedika (27) / (65) | | | Mustapha Bundu (41) / (80) | Charles (55) | | | Frederik Brandhof | Paulinho (57) | | | Mikael Anderson (24) / (40) / (71) | Gustav Isaksen (76) | | | Jon Thorsteinsson (71) | Evander Ferreira (89) | | | Patrick Mortensen (16) / (86) | Pione Sisto | | |
| | | Gift Links (71) | Jonas Lössl | | | Daniel Gadegaard Andersen | Dion Cools (76) | | | Jesper Juelsgård | Oliver Sørensen | | | Zachary Duncan (80) | Jens-Lys Cajuste (55) | | | Dawid Kurminowski (85) | Nikolas Dyhr (46) | | | Thomas Kristensen (86) | Mads Hansen (76) | | | Albert Grønbæk (71) | Victor Lind (65) | | |
| 07.11.2021 (18:00): BRØNDBY - OB | |
| | 8. | 0-1 | Mads Frøkjær-Jensen | Jakob Kehlet | | | 20. | 1-1 | Mikael Uhre | | | | 90. | 2-1 | Morten Frendrup | | | |
| | Mads Hermansen | Hans Christian Bernat | | | Henrik Heggheim | Nicholas Mickelson (85) | | | Andreas Maxsø | Jeppe Tverskov | | | Kevin Tshiembe | Alexander Juel Andersen | | | Kevin Mensah | Jørgen Skjelvik | | | Morten Frendrup (90) | Jens Jakob Thomasen | | | Josip Radosevic (77) | Aron Elis Thrandarson | | | Anis Ben Slimane (59) | Emmanuel Sabbi | | | Blas Riveros (59) | Mads Frøkjær-Jensen (8) / (83) | | | Mikael Uhre (20) / (77) | Moses Opondo (62) | | | Simon Hedlund (59) | Max Fenger (78) | | |
| | | Mathias Greve (59) | Kasper Larsen | | | Andrija Pavlovic (77) | Issam Jebali (62) | | | Thomas Mikkelsen | Bashkim Kadrii (83) | | | Andreas Bruus (59) | Mart Lieder (78) | | | Christian Cappis (77) | Tarik Ibrahimagic | | | Marko Divkovic (59) | Sayouba Mandé | | | Anton Skipper | Jakob Breum | | |
| 07.11.2021 (20:00): SILKEBORG - FC KØBENHAVN | |
| | | | | Mads-Kristoffer Kristoffersen | | |
| | Nicolai Larsen | Kamil Grabara | | | Rasmus Carstensen | Peter Ankersen (71) | | | Tobias Salquist | David Khocholava (47) | | | Joel Felix (67) | Nicolai Boilesen | | | Oliver Sonne | Victor Kristiansen | | | Anders Klynge (64) | Lukas Lerager (84) | | | Mark Brink (76) | Pep Biel | | | Robert Gojani | Kevin Diks | | | Sebastian Jørgensen (76) | Hakon Arnar Haraldsson (71) | | | Nicolai Vallys (89) | Jens Stage | | | Nicklas Helenius | Jonas Wind | | |
| | | Stefan Teitur Thordarson (64) | Ruben Gabrielsen | | | Søren Tengstedt (76) | Isak Bergmann Johannesson (84) | | | Stan van Bladeren | Andri Fannar Baldursson | | | Nicklas Røjkjær | Karl-Johan Johnsson | | | Andreas Oggesen (76) | William Bøving (71) | | | André Calisir | Rasmus Højlund (71) | | | Frederik Carstensen (89) | Elias Jelert | |
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