| 18.02.2022 (19:00): SØNDERJYSKE - AGF | |
| | 2. | 1-0 | Peter Christiansen | Mads-Kristoffer Kristoffersen | | | 14. | 2-0 | Stefan Gartenmann | | | | 34. | 2-1 | Patrick Mortensen | | | | 59. | 2-2 | Jon Thorsteinsson | | | | 90. | 2-3 | Patrick Mortensen | | | |
| | Lawrence Thomas | Jesper Hansen | | | Maxime Soulas | Anthony D'Alberto | | | Stefan Gartenmann  (14) | Sebastian Hausner | | | Marc Dal Hende  (76) | Yann Aurel Bisseck | | | Emil Holm (78) | Oliver Lund (16) | | | Emil Kornvig (9) /  (28) | Nicolai Poulsen (87) | | | Nikolaj Thomsen | Mustapha Bundu | | | Atli Barkarson (79) | Albert Grønbæk (56) | | | Emil Frederiksen (60) | Frederik Brandhof | | | Kristofer Kristinsson (79) | Jon Thorsteinsson (59) / (82) | | | Peter Christiansen (2) / (60) | Patrick Mortensen (34,90) | | |
| | | Duplexe Tchamba  (79) | Frederik Tingager | | | Faris Moumbagna (79) | Mikael Anderson (56) | | | José Gallegos (60) | Gift Links (82) | | | Rasmus Vinderslev (28) | Alexander Munksgaard | | | Robin Schouten | Daniel Gadegaard Andersen | | | Nicolai Flø | Dawid Kurminowski (87) | | | Isak Jensen (60) | Frederik Ihler | | |
| 19.02.2022 (14:00): FC MIDTJYLLAND - AAB | |
| | 28. | 0-1 | Daniel Granli | Morten Krogh | | | 56. | 0-2 | Kasper Høgh | | | |
| | Elias Olafsson | Jacob Rinne | | | Henrik Dalsgaard | Daniel Granli (28) | | | Erik Sviatchenko (6) | Rasmus Thelander | | | Juninho (61) | Anders Hagelskjær (90) | | | Joel Andersson | Kristoffer Pallesen (12) / (65) | | | Charles (23) / (50) | Malthe Højholt (33) | | | Raphael Onyedika | Magnus Christensen (87) | | | Nikolas Dyhr | Frederik Børsting (79) | | | Evander Ferreira (61) | Louka Prip | | | Junior Brumado (71) | Iver Fossum | | | Pione Sisto (61) | Milan Makaric (46) | | |
| | | Max Meier (61) | Jakob Ahlmann (79) | | | Mads Døhr Thychosen | Mathias Ross (65) | | | Vagner Love (61) | Kasper Kusk | | | Paulinho (61) | Anosike Ementa (87) | | | David Ousted | Kasper Høgh (46) / (56) | | | Victor Lind (50) | Theo Sander | | | Oscar Fraulo (71) / (90) | | | |
| 19.02.2022 (19:00): SILKEBORG - VEJLE | |
| | 45. | 1-0 | Nicklas Helenius | Jonas Hansen | | | 74. | 2-0 | Sebastian Jørgensen | | | | 78. | 3-0 | Nicolai Vallys | | | |
| | Nicolai Larsen | Alexander Brunst | | | Rasmus Carstensen | Thomas Gundelund (80) | | | Tobias Salquist | Raul Albertosa | | | André Calisir (67) | Denis Kolinger | | | Lukas Engel (69) / (89) | Heron | | | Anders Klynge | Lundrim Hetemi (58) | | | Mark Brink | Ebenezer Ofori (80) | | | Andreas Oggesen (69) | Arbnor Mucolli (34) | | | Sebastian Jørgensen (74) / (89) | Allan Sousa (43) / (75) | | | Nicolai Vallys (78) | Luka Djordjevic (46) | | | Nicklas Helenius (45) / (89) | Edgar Babyan (32) / (53) | | |
| | | Pelle Mattsson | Miiko Albernoz (53) / (68) | | | Søren Tengstedt (89) | Jerome Opoku | | | Stan van Bladeren | Mouhamadou Drammeh | | | Robert Gojani (69) | Andrés Ponce (46) | | | Nicklas Røjkjær (89) | Kevin Custovic (80) | | | Alexander Busch | Dimitrios Emmanoulidis (75) | | | Frederik Carstensen (89) | Lucas Hägg | | |
| 20.02.2022 (16:00): FC NORDSJÆLLAND - BRØNDBY | |
| | 57. | 0-1 | Anis Ben Slimane | Jens Maae | | | 66. | 0-2 | Andreas Bruus | | | |
| | Andreas Hansen | Mads Hermansen | | | Oliver Villadsen | Henrik Heggheim | | | Kian Hansen | Andreas Maxsø | | | Erik Marxen | Sigurd Rosted (45) | | | Daniel Svensson (64) | Andreas Bruus (66) | | | Mads Bidstrup (88) | Anis Ben Slimane (57) / (89) | | | Magnus Kofod Andersen (82) | Josip Radosevic (45) | | | Mads Kristian Hansen (82) | Joe Bell | | | Benjamin Nygren | Kevin Mensah | | | Andreas Schjelderup | Carl Björk (71) | | | Oliver Antman (64) | Marko Divkovic (85) | | |
| | | Martin Frese (64) | Mathias Greve (71) | | | Jacob Christensen (88) | Blas Riveros | | | Simon Adingra (64) | Kevin Tshiembe | | | Lasso Coulibaly (82) | Oskar Fallenius | | | Andreas Gülstorff | Christian Cappis (89) | | | Leo Walta (82) | Mathias Kvistgaarden (85) | | | Adamo Nagalo | Jonathan Ægidius | | |
| 20.02.2022 (18:00): FC KØBENHAVN - OB | |
| | 32. | 1-0 | Pep Biel | Sandi Putros | | | 75. | 2-0 | Khouma Babacar | | | |
| | Kamil Grabara | Hans Christian Bernat | | | Peter Ankersen (36) / (89) | Nicholas Mickelson (87) | | | Denis Vavro | Kasper Larsen | | | Nicolai Boilesen | Jeppe Tverskov | | | Victor Kristiansen | Joel King (87) | | | Roony Bardaghji (69) | Jens Jakob Thomasen | | | Lukas Lerager (33) | Issam Jebali | | | Jens Stage | Ayo Okosun | | | William Bøving (69) | Jakob Breum (87) | | | Pep Biel (32) | Bashkim Kadrii (73) | | | Nicolai Jørgensen (59) | Sander Svendsen (73) | | |
| | | David Khocholava | Alexander Juel Andersen | | | Khouma Babacar (59) / (75) | Emmanuel Sabbi (73) | | | Paul Mukairu (69) | Max Fenger (73) | | | Karl-Johan Johnsson | Jørgen Skjelvik (87) | | | Mamoudou Karamoko | Troels Kløve (87) | | | Rasmus Falk (69) | Robin Østrøm (87) | | | Elias Jelert (89) | Sayouba Mandé | | |
| 21.02.2022 (19:00): RANDERS FC - VIBORG | |
| | 7. | 0-1 | Younes Bakiz | Peter Kjærsgaard | | |
| | Patrik Carlgren | Lucas Lund Pedersen | | | Björn Kopplin | Daniel Anyembe (86) | | | Hugo Andersson (54) / (66) | Nicolas Bürgy | | | Simon Graves | Mads Lauritsen | | | Oliver Bundgaard | Christian Sørensen | | | Jakob Ankersen (84) | Justin Lonwijk (77) | | | Lasse Berg Johnsen (84) | Jeppe Grønning | | | Vito Hammershøy-Mistrati | Jakob Bonde (66) | | | Simon Tibbling (46) | Tobias Bech (66) | | | Stephen Odey | Jay-Roy Grot (89) | | | Nicolai Brock-Madsen (66) | Younes Bakiz (7) / (77) | | |
| | | Mattias Andersson (66) | Lorenzo Gordinho | | | Tosin Kehinde (46) / (68) | Frans Putros (86) | | | Frederik Lauenborg (66) | Alassana Jatta (77) | | | Tobias Klysner | Clint Leemans (66) | | | Jonas Dakir | Jan Zamburek (77) / (88) | | | Alexander Simmelhack (84) | Kasper Kiilerich | | | Filip Bundgaard (84) | Sofus Berger (66) | | |
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