| 25.02.2022 (19:00): VEJLE - AGF | |
| | 4. | 0-1 | Mustapha Bundu | Jakob A. Sundberg | | | 10. | 1.-1 | Raul Albentosa | | | | 17. | 1-2 | Nicolai Poulsen | | | | 42. | 2-2 | Arbnor Mucolli | | | | 90. | 3-2 | Mouhamadou Drammeh | | | |
| | Alexander Brunst | Jesper Hansen | | | Thomas Gundelund  (86) | Anthony D'Alberto | | | Denis Kolinger | Yann Aurel Bisseck | | | Raul Albertosa  (10) | Sebastian Hausner | | | Heron  (79) | Eric Kahl (90) | | | Mouhamadou Drammeh (90) | Nicolai Poulsen (17) / (83) | | | Ebenezer Ofori (90) | Mustapha Bundu (4) / (90) | | | Edgar Babyan (77) / (90) | Albert Grønbæk (74) | | | Allan Sousa | Mikael Anderson (90) | | | Andrés Ponce (86) | Jon Thorsteinsson (45) / (74) | | | Arbnor Mucolli (42) / (43) / (86) | Patrick Mortensen | | |
| | | Miiko Albernoz | Frederik Tingager | | | Jerome Opoku  (90) | Jack Wilshere (90) | | | Dimitrios Emmanoulidis (86) | Gift Links (74) | | | Luka Djordjevic (86) | Alexander Munksgaard (90) | | | Lucas Hägg | Daniel Gadegaard Andersen | | | Hans Høllsberg (86) | Dawid Kurminowski (90) | | | Lundrim Hetemi (90) | Frederik Brandhof (74) | | |
| 27.02.2022 (14:00): AAB - SILKEBORG | |
| | 66. | 0-1 | Nicklas Helenius | Mikkel Redder | | | 69. | 0-2 | Nicklas Helenius, straffe | | | | 72. | 0-3 | Sebastian Jørgensen | | | | 78. | 0-4 | Nicklas Helenius | | | | 83. | 1-4 | Kasper Høgh | | | |
| | Jacob Rinne | Nicolai Larsen | | | Mathias Ross (46) | Rasmus Carstensen | | | Rasmus Thelander | Tobias Salquist | | | Anders Hagelskjær | Alexander Busch | | | Daniel Granli | Lukas Engel | | | Malthe Højholt (46) | Anders Klynge (90) | | | Magnus Christensen (62) | Mark Brink (86) | | | Frederik Børsting (27) / (84) | Andreas Oggesen (77) | | | Iver Fossum | Sebastian Jørgensen (72) / (77) | | | Louka Prip | Nicolai Vallys | | | Milan Makaric (79) | Nicklas Helenius (66,69,78) / (86) | | |
| | | Kristoffer Pallesen (46) | Pelle Mattsson (86) | | | Jakob Ahlmann (84) | Stefan Teitur Thordarson (90) | | | Anosike Ementa (79) | Søren Tengstedt (77) | | | Rufo (46) / (69) | Stan van Bladeren | | | Anders Noshe | Robert Gojani (77) /  (90) | | | Kasper Høgh (62) / (83) | Nicklas Røjkjær | | | Theo Sander | Frederik Carstensen (86) | | |
| 27.02.2022 (14:00): FC NORDSJÆLLAND - RANDERS FC | |
| FC NORDSJÆLLAND | RANDERS FC | |
| | Andreas Hansen | Patrik Carlgren | | | Oliver Villadsen | Mikkel Kallesøe (55) | | | Kian Hansen | Simon Piesinger | | | Erik Marxen | Simon Graves | | | Daniel Svensson (73) | Björn Kopplin | | | Mads Bidstrup (81) | Simon Tibbling (66) | | | Magnus Kofod Andersen | Lasse Berg Johnsen (68) | | | Mads Kristian Hansen | Frederik Lauenborg (85) | | | Andreas Schjelderup (89) | Jakob Ankersen (66) | | | Simon Adingra (51) / (73) | Vito Hammershøy-Mistrati (32) | | | Oliver Antman (89) | Stephen Odey | | |
| | | Martin Frese (73) | Mattias Andersson | | | Jacob Christensen (81) | Jesper Lauridsen (85) | | | Mohamed Diomande (73) | Tobias Klysner (66) | | | Emmanuel Ogura | Oliver Bundgaard (55) | | | Rocco Ascone (89) | Jonas Dakir | | | Adamo Nagalo | Filip Bundgaard (66) | | | Yannick Agnero (89) / (90) | Nicolai Brock-Madsen | | |
| 27.02.2022 (16:00): VIBORG - FC KØBENHAVN | |
| | 30. | 0-1 | Denis Vavro | Jakob Kehlet | | | 90. | 0-2 | Nicolai Jørgensen | | | |
| | Lucas Lund Pedersen | Kamil Grabara | | | Daniel Anyembe (65) | Peter Ankersen (80) | | | Nicolas Bürgy | Denis Vavro (30) | | | Mads Lauritsen | Nicolai Boilesen | | | Christian Sørensen | Victor Kristiansen | | | Justin Lonwijk (77) | Jens Stage | | | Jeppe Grønning (77) | Rasmus Falk | | | Jakob Bonde | Roony Bardaghji (71) | | | Tobias Bech (87) | Pep Biel | | | Jay-Roy Grot | Paul Mukairu (80) | | | Younes Bakiz | Khouma Babacar (56) | | |
| | | Lorenzo Gordinho | Kevin Diks (80) | | | Frans Putros (65) | David Khocholava | | | Alassana Jatta (87) | Nicolai Jørgensen (56) / (90) | | | Clint Leemans (77) | Lukas Lerager (71) | | | Mikkel Andersen | Karl-Johan Johnsson | | | Jan Zamburek (77) | William Bøving (80) | | | Sofus Berger | Mamoudou Karamoko | | |
| 27.02.2022 (18:00): OB - FC MIDTJYLLAND | |
| | 52. | 0-1 | Junior Brumado | Jørgen Daugbjerg Burchardt | | | 59. | 1-1 | Issam Jebali | | | | 62. | 2-1 | Selvmål, Erik Sviatchenko | | | | 90. | 2-2 | Vagner Love | | | |
| | Hans Christian Bernat | Elias Olafsson | | | Nicholas Mickelson | Henrik Dalsgaard | | | Alexander Juel Andersen | Erik Sviatchenko  (62) | | | Jeppe Tverskov (20) | Daniel Høegh | | | Joel King (55) | Joel Andersson (86) | | | Ayo Okosun (77) | Max Meier (74) | | | Jens Jakob Thomasen (74) | Raphael Onyedika | | | Emmanuel Sabbi (66) | Evander Ferreira (80) | | | Issam Jebali (59) / (90) | Nikolas Dyhr (86) | | | Sander Svendsen (88) | Gustav Isaksen (80) | | | Bashkim Kadrii (74) | Junior Brumado (52) | | |
| | | Jakob Breum (66) | Pione Sisto (74) | | | Max Fenger (74) | Mads Døhr Thychosen (86) | | | Jørgen Skjelvik (88) | Vagner Love (86) / (90) | | | Mathias Brems | Paulinho | | | Troels Kløve (74) | David Ousted | | | Robin Østrøm | Charles (80) | | | Sayouba Mandé | Victor Lind (80) | | |
| 28.02.2022 (19:00): BRØNDBY - SØNDERJYSKE | |
| | 25. | 1-0 | Henrik Heggheim | Peter Kjærsgaard | | |
| | Mads Hermansen | Lawrence Thomas | | | Henrik Heggheim (25) / (76) | Maxime Soulas (79) | | | Andreas Maxsø | Stefan Gartenmann | | | Sigurd Rosted | Marc Dal Hende | | | Andreas Bruus | Emil Holm | | | Anis Ben Slimane | Mads Albæk (81) / (83) | | | Simon Hedlund (61) | Nikolaj Thomsen (27) /  (38) | | | Joe Bell (68) | Atli Barkarson (79) | | | Kevin Mensah | Emil Frederiksen (79) | | | Anis Ben Slimane (82) | Kristofer Kristinsson | | | Carl Björk (73) | Peter Christiansen (29) / (71) | | |
| | | Mathias Greve (61) | Duplexe Tchamba (79) | | | Blas Riveros | Faris Moumbagna (79) | | | Thomas Mikkelsen | José Gallegos (79) | | | Kevin Tshiembe | Rasmus Vinderslev (71) | | | Oskar Fallenius | Robin Schouten | | | Christian Cappis (82) | Nicolai Flø | | | Mathias Kvistgaarden (73) | Isak Jensen (83) | | |
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