| 27.08.2021 (19:00): AAB - FC NORDSJÆLLAND | |
| | 1. | 0-1 | Mohammed Diomande | Aydin Uslu | | | 13. | 1-1 | Rasmus Thelander | | | | 49. | 2-1 | Iver Fossum | | | |
| | Jacob Rinne | Eduardo dos Santos Haesler | | | Mathias Ross (76) | Mads Døhr Tychosen | | | Rasmus Thelander (13) | Kian Hansen | | | Daniel Granli | Adamo Nagalo | | | Kristoffer Pallesen (69) | Oliver Villadsen | | | Malthe Højholt (65) / (76) | Abu Francis (72) | | | Pedro Ferreira | Magnus Kofod Andersen | | | Jakob Ahlmann (90) | Martin Frese (72) | | | Iver Fossum (49) | Mohamed Diomande (1) / (77) | | | Louka Prip (88) | Lasso Coulibaly (51) / (86) | | | Milan Makaric (69) | Andreas Schjelderup (86) | | |
| | | Tim Prica (69) | Maxwell Woledzi (86) | | | Anders Hagelskjær (76) | Jacob Christensen (86) | | | Magnus Christensen (76) | Simon Adingra (72) | | | Kasper Kusk | Ivan Mesik | | | Andreas Hansen | Daniel Svensson (72) | | | Frederik Børsting (69) | Andreas Gülstorff | | | Marcus Hannesbo (88) | Leo Walta (77) | | |
| 29.08.2021 (14:00): SØNDERJYSKE - VIBORG | |
| | 26. | 1-0 | Emil Kornvig | Jens Maae | | | 31. | 1-1 | Jeppe Grønning | | | | 57. | 1-2 | Sebastian Grønning | | | | 66. | 2-2 | Daniel Prosser | | | |
| | Lawrence Thomas | Jacob Rinne | | | Emil Holm | Frans Putros (89) | | | Stefan Gartenmann | Lars Kramer | | | Duplexe Tchamba | Mads Lauritsen (86) | | | Marc Dal Hende | Christian Sørensen | | | Mads Albæk | Jakob Bonde | | | Victor Ekani (87) | Jeppe Grønning (31) | | | Emil Kornvig (26) | Sofus Berger (64) | | | Rilwan Hassan (65) | Tobias Bech (75) | | | Andulrahman Taiwo | Sebastian Grønning (45) / (57) / (87) | | | Kristofer Kristinsson (65) | Ibrahim Said (55) / (65) | | |
| | | Philipp Schmiedl | Justin Lonwijk (64) | | | Daniel Prosser (65) / (66) | Jeff Mensah (65) / (74) | | | Jeppe Simonsen | Jay-Roy Grot (75) | | | Emil Frederiksen | Alassana Jatta (87) | | | Rasmus Vinderslev (87) | Clint Leemans | | | Nicolai Flø | Daniel Anyembe | | | Isak Steiner Jensen (65) | Can Dursun | | |
| 29.08.2021 (14:00): SILKEBORG - RANDERS FC | |
| | 26. | 1-0 | Nicklas Helenius | Jakob Kehlet | | | 49. | 2-0 | Nicolai Vallys | | | | 54. | 2-1 | Vito Hammershøy-Mistrati | | | |
| | Nicolai Larsen | Patrik Carlgren | | | Rasmus Carstensen | Tobias Klysner | | | Tobias Salquist | Simon Piesinger | | | André Calisir | Simon Graves | | | Oliver Sonne (90) | Jesper Lauridsen (85) | | | Stefan Teitur Thordarson (55) | Vincent Onovo (46) | | | Mark Brink (83) | Lasse Berg Johnsen | | | Anders Klynge | Vito Hammershøy-Mistrati (54) / (75) | | | Sebastian Jørgensen (90) | Tosin Kehinde (63) | | | Nicklas Helenius (26) / (83) | Alhaji Kamara (75) | | | Nicolai Vallys (49) | Jakob Ankersen (67) | | |
| | | Joel Felix (90) | Simon Tibbling (46) | | | Pelle Mattsson (83) | Frederik Lauenborg (67) | | | Stan van Bladeren | Oliver Bundgaard (85) | | | Gustav Marcussen (90) | Issah Salou | | | Nicklas Røjkjær | Jonas Dakir | | | Andreas Oggesen (55) | Filip Bundgaard (75) | | | Wessam Abou Ali (83) | Marvin Egho (75) | | |
| 29.08.2021 (16:00): VEJLE - FC KØBENHAVN | |
| | 18. | 0-1 | Lukas Lerager | Jonas Hansen | | | 24. | 0-2 | Pep Biel | | | | 54. | 0-3 | Carlos Zega | | | | 78. | 0-4 | Jens Stage | | | |
| | Alexander Brunst | Kamil Grabara | | | Tobias Mølgaard (58) | Kevin Diks (81) | | | Denis Kolinger | David Khocholava | | | Jerome Opoku (46) | Nicolai Boilesen | | | Viljormur Davidsen | Victor Kristiansen (65) / (70) | | | Saeid Ezatolahi (46) | Lukas Lerager (18) | | | Allan Sousa (7) / (84) | Carlos Zeca (54) / (70) | | | Arbnor Mucolli | Jens Stage (78) | | | Hans Høllsberg | Pep Biel (24) / (81) | | | Dimitrios Emmanouilidis (73) | William Bøving (81) | | | Wahid Faghir | Jonas Wind | | |
| | | Heron (58) | Pierre Bengtsson (70) | | | Mouhamadou Drammeh (46) | Luther Singh (81) | | | Lukas Engel (84) | Andri Fannar Baldursson (70) / (86) | | | Manjrekar James (46) | Karl-Johan Johnsson | | | Tobias Haahr Jakobsen | Peter Ankersen (81) | | | Brandon Pierrick (73) | Rasmus Højlund (81) | | | Lundrim Hetemi | Marko Stamenic | | |
| 29.08.2021 (18:00): AGF - OB | |
| | 1. | 0-1 | Alexander Juel Andersen | Michael Tykgaard | | | 3. | 1-1 | Eric Kahl | | | | 16. | 2-1 | Eric Kahl | | | | 90. | 2-2 | Moses Opondo | | | |
| | Jesper Hansen | Hans Christian Bernat | | | Frederik Tingager | Alexander Juel Andersen (1) / (66) | | | Yann Aurel Bisseck | Kasper Larsen | | | Sebastian Hausner | Jeppe Tverskov | | | Oliver Lund (75) / (89) | Jørgen Skjelvik | | | Albert Grønbæk (81) / (84) | Aron Elis Thrandarson (7) / (78) | | | Nicolai Poulsen (34) | Troels Kløve | | | Frederik Brandhof (26) / (70) | Emmanuel Sabbi (18) / (78) | | | Eric Kahl (3,16) | Issam Jebali (65) / (66) | | | Patrick Mortensen | Mads Frøkjær-Jensen (35) | | | Jon Thorsteinsson (7) / (70) | Bashkim Kadrii (78) | | |
| | | Patrick Olsen (70) | Mart Lieder (66) | | | Gift Links | Max Fenger (78) | | | Alexander Munksgaard (89) | Ayo Okosun (78) / (90) | | | Søren Tengstedt (84) | Tarik Ibrahimagic | | | Jesper Juelsgård | Robin Østrøm (66) | | | Dawid Kurminowski (70) | Moses Opondo (78) / (90) | | | Daniel Gadegaard Andersen | Sayouba Mandé | | |
| 29.08.2021 (20:00): BRØNDBY - FC MIDTJYLLAND | |
| | 54. | 1-0 | Anis Ben Slimane | Sandi Putros | | | 66. | 2-0 | Mikael Uhre | | | |
| | Mads Hermansen | Jonas Lössl | | | Anton Skipper (19) | Henrik Dalsgaard | | | Andreas Maxsø | Erik Sviatchenko (49) | | | Kevin Tshiembe | Paulinho (83) | | | Andreas Bruus | Joel Andersson | | | Mathias Greve (46) | Raphael Onyedika | | | Josip Radosevic | Evander Ferreira | | | Anis Ben Slimane (54) / (86) | Nikolas Dyhr (63) | | | Kevin Mensah | Pione Sisto (83) | | | Mikael Uhre (66) / (74) | Gustav Isaksen (74) | | | Simon Hedlund (86) | Awer Mabil (74) | | |
| | | Sigurd Rosted | Daniel Høegh | | | Andrija Pavlovic (74) | Elias Olafsson | | | Thomas Mikkelsen | Oliver Sørensen (83) | | | Morten Frendrup (19) | Charles (63) / (90) | | | Oskar Fallenius (86) | Nicolas Madsen (83) | | | Christian Cappis (46) | Mads Hansen (74) | | | Tobias Børkeeiet (86) | Aral Simsir (74) | | |
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