| 22.10.2021 (19:00): VEJLE - FC NORDSJÆLLAND | |
| | 24. | 1-0 | Selvmål, Lasso Coulibaly | Jonas Hansen | | | 33. | 2-0 | Andrés Ponce | | | |
| | Sten Grytebust | Emmanuel Ogura | | | Tobias Mølgaard | Mads Døhr Tychosen | | | Manjrekar James | Maxwell Woledzi | | | Denis Kolinger | Adamo Nagalo | | | Heron | Oliver Villadsen (46) | | | Allan Sousa (90) | Abu Francis (67) | | | Jacob Schoop (83) | Magnus Kofod Andersen | | | Saeid Ezatolahi (90) | Martin Frese | | | Lukas Engel (83) | Simon Adingra (78) | | | Hallur Hansson | Andreas Bredahl (46) | | | Andrés Ponce (33) / (69) | Lasso Coulibaly (24) / (67) | | |
| | | Alexander Brunst | Eduardo dos Santos Haesler | | | Viljormur Davidsen (83) | Jacob Christensen (46) | | | Mouhamadou Drammeh (83) | Andreas Schjelderup (46) | | | Kevin Custovic | Oliver Antman (78) | | | Luka Djordjevic (69) | Jonas Jensen-Abbew | | | Hans Høllsberg (90) | William Kumado (67) | | | Adam Fofana (90) | Yannick Agnero (67) | | |
| 24.10.2021 (14:00): BRØNDBY - FC KØBENHAVN | |
| | 23. | 1-0 | Morten Frendrup | Peter Kjærsgaard | | | 57. | 2-0 | Andreas Maxsø, straffe | | | | 64. | 2-1 | Jonas Wind | | | |
| | Thomas Mikkelsen | Kamil Grabara (57) | | | Henrik Heggheim (55) / (76) | Kevin Diks | | | Andreas Maxsø (57) | David Khocholava (73) | | | Sigurd Rosted | Nicolai Boilesen | | | Andreas Bruus (36) / (66) | Victor Kristiansen | | | Morten Frendrup (23) | Isak Bergmann Johannesson (65) | | | Josip Radosevic | Lukas Lerager (26) | | | Anis Ben Slimane | Jens Stage | | | Kevin Mensah | Pep Biel | | | Mikael Uhre (84) | William Bøving (46) | | | Simon Hedlund (69) / (76) | Jonas Wind (64) | | |
| | | Mathias Greve | Ruben Gabrielsen | | | Andrija Pavlovic (84) | Andri Fannar Baldursson | | | Blas Riveros (66) | Karl-Johan Johnsson | | | Kevin Tshiembe (76) | Peter Ankersen | | | Christian Cappis | Rasmus Højlund (46) | | | Marko Divkovic (76) | Hakon Arnar Haraldsson | | | Jonathan Ægidius | Elias Jelert (65) | | |
| 24.10.2021 (14:00): SILKEBORG - OB | |
| | 74. | 1-0 | Sebastian Jørgensen | Sandi Putros | | | 90. | 1-1 | Max Fenger | | | |
| | Nicolai Larsen | Hans Christian Bernat | | | Rasmus Carstensen | Nicholas Mickelson | | | Tobias Salquist | Jeppe Tverskov | | | André Calisir (45) | Alexander Juel Andersen | | | Oliver Sonne (90) | Jørgen Skjelvik | | | Stefan Teitur Thordarson (45) | Jens Jakob Thomasen | | | Mark Brink | Aron Elis Thrandarson (88) | | | Robert Gojani (78) | Emmanuel Sabbi | | | Sebastian Jørgensen (74) / (81) / (88) | Mads Frøkjær-Jensen (71) | | | Nicolai Vallys | Troels Kløve (77) | | | Nicklas Helenius | Bashkim Kadrii (71) | | |
| | | Aske Andresen | Kasper Larsen | | | Gustav Marcussen | Mart Lieder (71) | | | Anders Klynge (45) | Max Fenger (71) / (90) | | | Nicklas Røjkjær (88) | Robin Østrøm | | | Andreas Oggesen (78) | Moses Opondo (77) | | | Alexander Busch | Sayouba Mandé | | | Frederik Carstensen | Jakob Breum (88) | | |
| 24.10.2021 (16:00): RANDERS FC - AGF | |
| | 19. | 1-0 | Selvmål, Frederik Brandhof | Morten Krogh | | |
| | Patrik Carlgren | Jesper Hansen | | | Mikkel Kallesøe (90) | Anthony D'Alberto (76) | | | Simon Piesinger | Frederik Tingager (62) | | | Simon Graves (56) | Yann Aurel Bisseck | | | Björn Kopplin | Eric Kahl (61) | | | Simon Tibbling (80) / (83) | Patrick Olsen | | | Lasse Berg Johnsen | Mustapha Bundu (43) / (61) | | | Vito Hammershøy-Mistrati | Albert Grønbæk | | | Jakob Ankersen (67) | Frederik Brandhof (19) / (70) | | | Nicolai Brock-Madsen (67) | Jon Thorsteinsson (70) | | | Stephen Odey (84) | Patrick Mortensen (39) | | |
| | | Tosin Kehinde (67) | Gift Links (70) | | | Jesper Lauridsen (56) | Oliver Lund (76) | | | Oliver Bundgaard (83) | Daniel Gadegaard Andersen | | | Jonas Dakir | Jesper Juelsgård (61) / (77) | | | Vincent Onovo | Zachary Duncan (70) | | | Marvin Egho (67) / (71) | Dawid Kurminowski (61) | | | Alhaji Kamara (84) | Thomas Kristensen | | |
| 24.10.2021 (18:00): FC MIDTJYLLAND - SØNDERJYSKE | |
| | 6. | 0-1 | Emil Holm | Jakob Kehlet | | | 42. | 1-1 | Evander Ferreira | | | | 54. | 2-1 | Erik Sviatchenko | | | | 90. | 2-2 | Emil Frederiksen | | | | 90. | 3-2 | Mads Hansen | | | |
| FC MIDTJYLLAND | SØNDERJYSKE | |
| | Elias Olafsson | Lawrence Thomas | | | Daniel Høegh (57) | Emil Holm (6) / (46) | | | Erik Sviatchenko (54) | Stefan Gartenmann | | | Paulinho | Duplexe Tchamba | | | Joel Andersson | Marc Dal Hende | | | Raphael Onyedika | Julius Eskesen (72) | | | Evander Ferreira (42) | Victor Ekani (67) / (83) | | | Nikolas Dyhr (77) | Mads Albæk (89) | | | Gustav Isaksen (65) | Daniel Prosser (72) | | | Victor Lind (77) | Abdulrahman Taiwo | | | Pione Sisto | Jeppe Simonsen | | |
| | | Jonas Lössl | Søren Reese | | | Dion Cools (77) | Emil Kornvig (72) | | | Awer Mabil (65) | Kristofer Kristinsson (83) | | | Charles | Emil Frederiksen (72) / (90) | | | Mads Hansen (77) / (90) | Nicolai Flø | | | Oscar Fraulo | Isak Steiner Jensen (89) | | | Juninho (57) | Rilwan Hassan (46) | | |
| 25.10.2021 (19:00): AAB - VIBORG | |
| | 9. | 0-1 | Jakob Bonde, straffe | Michael Tykgaard | | | 45. | 0-2 | Younes Bakiz | | | | 45. | 1-2 | Louka Prip | | | | 51. | 1-3 | Justin Lonwijk | | | | 69. | 1-4 | Clint Leemans | | | | 76. | 2-4 | Milan Makaric | | | | 79. | 2-5 | Mads Lauritsen | | | |
| | Jacob Rinne | Mikkel Andersen | | | Daniel Granli | Frans Putros | | | Rasmus Thelander | Lars Kramer | | | Anders Hagelskjær (74) | Mads Lauritsen (79) | | | Kristoffer Pallesen (74) | Christian Sørensen | | | Malthe Højholt | Jakob Bonde (9) | | | Pedro Ferreira (46) | Jay-Roy Grot (77) | | | Frederik Børsting (83) | Justin Lonwijk (51) / (81) | | | Iver Fossum | Clint Leemans (69) / (77) | | | Louka Prip (45) | Younes Bakiz (45) / (52) | | | Aleksandar Trajkovski (46) | Sebastian Grønning | | |
| | | Jakob Ahlmann (74) | Lorenzo Gordinho | | | Milan Makaric (46) / (76) | Alassana Jatta | | | Tim Prica (46) | Mads Aaquist (81) | | | Magnus Christensen | Sofus Berger (77) | | | Kasper Kusk (83) | Ibrahim Said (77) | | | Andreas Hansen | Tobias Bech (52) | | | Marcus Hannesbo (74) | Christian Hauge | | |
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