| Real Madrid til semifinaler med sammenlagt 4-3 | |
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| 23.02.1966 | Anderlecht - Real Madrid 1-0
| | | | 1-0 Paul van Himst (2)
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| | 09.03.1966 | Real Madrid - Anderlecht 4-2
| | | | 1-0 Amancio Amaro (13) ; 2-0 Amancio Amaro (35) ; 3-0 Francisco Gento (60) ; 4-0 Francisco Gento, straffe (83) ; 4-1 Joseph Jurion (89) ; 4-2 Wilfried Puis (90)
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| Inter til semifinaler med sammenlagt 5-1 | |
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| 23.02.1966 | Inter - Ferencvaros 4-0
| | | | 1-0 Jair (8) ; 2-0 Mario Corso (36) ; 3-0 Joaquin Peiro (65) ; 4-0 Joaquin Peiro (73)
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| | 02.03.1966 | Ferencvaros - Inter 1-1
| | | | 1-0 Dezsö Novak, straffe (31) ; 1-1 Angelo Domenghini (62)
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| Manchester United til semifinaler med sammenlagt 8-3 | |
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| 02.02.1966 | Manchester United - Benfica 3-2 (2-1)
| | | | 0-1 Jose Augusto (30) ; 1-1 David Herd (36) ; 2-1 Denis Law (44) ; 3-1 Bill Foulkes (58) ; 3-2 Jose Torres (70)
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| | 09.03.1966 | Benfica - Manchester United 1-5 (0-3)
| | | | 0-1 George Best (6) ; 0-2 George Best (13) ; 0-3 John Connelly (15) ; 1-3 Selvmål, Seamus Brennan (52) ; 1-4 Pat Crerand (78) ; 1-5 Bobby Charlton (89)
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| Partizan Beograd til semifinaler med sammenlagt 6-4 | |
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| 02.03.1966 | Sparta Prag - Partizan Beograd 4-1
| | | | 0-1 Mustafa Hasanagic (16) ; 1-1 Andrej Kvasnak (22) ; 2-1 Andrej Kvasnak, straffe (57) ; 3-1 Vaclav Masek (73) ; 4-1 Andrej Kvasnak (90)
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| | 09.03.1966 | Partizan Beograd - Sparta Prag 5-0 (4-0)
| | | | 1-0 Vladimir Kovacevic (4) ; 2-0 Velibor Vasovic (23) ; 3-0 Vladimir Kovacevic (29) ; 4-0 Mustafa Hasanagic (35) ; 5-0 Mustafa Hasanagic (71)
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