| Dukla Prag til 2. runde med sammenlagt 6-0 | |
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| 28.09.1966 | Esbjerg - Dukla Prag 0-2
| | | | 0-1 Selvmål, Børge Enemark (63) ; 0-2 Milan Dvorak (67)
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| | 04.10.1966 | Dukla Prag - Esbjerg 4-0
| | | | 1-0 Stanislav Strunc (17) ; 2-0 Josef Vacenovsky (44) ; 3-0 Ivan Mraz (47) ; 4-0 Josef Vacenovsky (57)
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| 1860 München til 2. runde med sammenlagt 10-1 | |
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| 20.09.1966 | 1860 München - Omonia Nicosia 8-0
| | | | 1-0 Friedheim Konietzka (5) ; 2-0 Hans Küppers (8) ; 3-0 Friedheim Konietzka (23) ; 4-0 Wilfried Kohlars (27) ; 5-0 Hans Küppers (35) ; 6-0 Friedheim Konietzka (55) ; 7-0 Wilfried Kohlars (64) ; 8-0 Friedheim Konietzka (80)
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| | 25.09.1966 | Omonia Nicosia - 1860 München 1-2
| | | | 0-1 Wilfried Kohlars (33) ; 0-2 Rudolf Brunnmeier, straffe (60) ; 1-2 Andreas Haralampous (79)
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| Vojvodina Novi Sad til 2. runde med sammenlagt 1-0 | |
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| 07.09.1966 | Admira - Vojvodina Novi Sad 0-1
| | | | 0-1 Stevan Sekerec (80)
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| | 20.09.1966 | Vojvodina Novi Sad - Admira 0-0
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| Ajax til 2. runde med sammenlagt 4-1 | |
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| 28.09.1966 | Ajax - Besiktas 2-0
| | | | 1-0 Piet Keizer (16) ; 2-0 Bennie Muller (86)
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| | 05.10.1966 | Besiktas - Ajax 1-2
| | | | 1-0 Karadogan Faruk (53) ; 1-1 Sjaak Swart (61) ; 1-2 Piet Keizer (90)
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| Linfield til 2. runde med sammenlagt 9-4 | |
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| 07.09.1966 | Aris Bonnevoie - Linfield 3-3
| | | | 1-0 Bertrand Heger (1) ; 1-1 Bryan Hamilton (33) ; 1-2 Phil Scott (48) ; 1-3 Sammy Pavis (58) ; 2-3 Nicolas Hoffmann (60) ; 3-3 Josy Kirchens (68)
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| | 14.09.1966 | Linfield - Aris Bonnevoie 6-1
| | | | 1-0 Arthur Thomas (8) ; 2-0 Phil Scott (16) ; 3-0 Arthur Thomas (24) ; 4-0 Arthur Thomas (70) ; 5-0 Sammy Pavis (81) ; 6-0 Phil Scott (82) ; 6-1 Johny Schreiner (83)
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| Celtic til 2. runde med sammenlagt 5-0 | |
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| 28.09.1966 | Celtic - FC Zürich 2-0
| | | | 1-0 Tommy Gemmell (61) ; 2-0 Joe McBride (69)
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| | 05.10.1966 | FC Zürich - Celtic 0-3
| | | | 0-1 Tommy Gemmell (22) ; 0-2 Steve Chalmers (39) ; 0-3 Tommy Gemmell,straffe (48)
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| CSKA Sofia til 2. runde med sammenlagt 3-2 | |
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| 28.09.1966 | CSKA Sofia - Olympiakos Piræus 3-1
| | | | 0-1 Aristidis Papazoglu (30) ; 1-1 Ivan Vasillev (59) ; 2-1 Dimitar Penev (64) ; 3-1 Nicola Tsanev (89)
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| | 05.10.1966 | Olympiakos Piræus - CSKA Sofia 1-0
| | | | 1-0 Georgios Sideris, straffe (15)
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| Gornik Zabrze til 2. runde med sammenlagt 6-4 | |
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| 28.09.1966 | Gornik Zabrze - Vorwärts Berlin 2-1
| | | | 1-0 Ernest Pol, straffe (38) ; 1-1 Otto Frässdorf (58) ; 2-1 Ernest Pol (72)
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| | 12.10.1966 | Vorwärts Berlin - Gornik Zabrze 2-1
| | | | 1-0 Jürgen Piepenburg (25) ; 2-0 Jürgen Nöldner (33) ; 2-1 Wlodzimierz Lubanski (35)
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| | 26.10.1966 | Gornik Zabrze - Vorwärts Berlin 3-1
| | | | 1-0 Wlodzimierz Lubanski (8) ; 2-0 Ernest Pol (24) ; 3-0 Wlodzimierz Lubanski (55) ; 3-1 Peter Kalinke (74)
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| Anderlecht til 2. runde med sammenlagt 12-1 | |
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| 14.09.1966 | Haka Valkeakoski - Anderlecht 1-10
| | | | 1-0 Asko Mäkilä (4) ; 1-1 Paul van Himst (5) ; 1-2 Paul van Himst (12) ; 1-3 Johan Devrindt (16) ; 1-4 Paul van Himst (28) ; 1-5 Wilfried Puis (31) ; 1-6 Jorge Cayuela (40) ; 1-7 Johan Devrindt (42) ; 1-8 Paul van Himst (52) ; 1-9 Paul van Himst (58) ; 1-10 Johan Devrindt (75)
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| | 28.09.1966 | Anderlecht - Haka Valkeakoski 2-0
| | | | 1-0 Paul van Himst (25) ; 2-0 Johan Devrindt (61)
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| Inter til 2. runde med sammenlagt 1-0 | |
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| 14.09.1966 | Inter - Torpedo Moskva 1-0
| | | | 1-0 Selvmål, Valery Voronin (63)
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| | 28.09.1966 | Torpedo Moskva - Inter 0-0
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| Nantes til 2. runde med sammenlagt 8-4 | |
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| 07.09.1966 | KR Reykjavik - Nantes 2-3
| | | | 0-1 Philippe Gondel (6) ; 0-2 Jacques Simon (10) ; 1-2 Ellert Schram, straffe (43) ; 1-3 Philippe Gondel (62) ; 2-3 Ellert Schram (82)
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| | 05.10.1966 | Nantes - KR Reykjavik 5-2
| | | | 1-0 Jean-Claude Suadeau (8) ; 2-0 Jacques Simon (9) ; 3-0 Francis Magny (42) ; 3-1 Baldvin Baldvinsson (58) ; 4-1 Henry Michel (63) ; 5-1 Francis Magny (65) 5-2 Hordur Markan (77)
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| Liverpool til 2. runde med sammenlagt 5-3 | |
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| 14.09.1966 | Liverpool - Petrolul Ploiesti 2-0
| | | | 1-0 Ian St. John (70) ; 2-0 Ian Callaghan (77)
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| | 28.09.1966 | Petrolul Ploiesti - Liverpool 3-1
| | | | 1-0 Constantin Moldoveanu (36) ; 1-1 Roger Hunt (50) ; 2-1 Alexandru Boc (59) ; 3-1 Mircea Dridea (65)
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| | 19.10.1966 | Liverpool - Petrolul Ploiesti 2-0
| | | | 1-0 Ian St. John (13) ; 2-0 Peter Thompson (40)
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| Atletico Madrid til 2. runde med sammenlagt 5-1 | |
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| 14.09.1966 | Malmö FF - Atletico Madrid 0-2
| | | | 0-1 Josë Cardona (44) ; 0-2 Luis Aragones (45)
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| | 28.09.1966 | Atletico Madrid - Malmö FF 3-1
| | | | 1-0 Luis Aragones (19) ; 1-1 Ingvar Svahn (22) ; 2-1 Jorge Mendonca (56) ; 3-1 José Urtiaga (64)
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| Vasas Budapest til 2. runde med sammenlagt 7-0 | |
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| 05.10.1966 | Vasas Budapest - Sporting Lissabon 5-0
| | | | 1-0 Sandor Bakos (29) ; 2-0 Janos Farkas (52) ; 3-0 Lajos Puskas (57) ; 4-0 Janos Farkas (64) ; 5-0 Lajos Puskas (89)
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| | 12.10.1966 | Sporting Lissabon - Vasas Budapest 0-2
| | | | 0-1 Tibor Pal (80) ; 0-2 Lajos Puskas (88)
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