|   Grasshoppers til 2. runde | |
| | 17.09.1980 | Grasshoppers - KB 3-1 | | | | 01.10.1980 | KB - Grasshoppers 2-5 | |
|   FC Köln til 2. runde | |
| | 16.09.1980 | IA Akranes - FC Köln 0-4 | | | | 01.10.1980 | FC Köln - IA Akranes 6-0 | |
|   FC Barcelona til 2. runde | |
| | 16.09.1980 | Sliema Wanderers - FC Barcelona 0-2 | | | | 01.10.1980 | FC Barcelona - Sliema Wanderers 1-0 | |
|  Sociedad til 2. runde | |
| | 16.09.1980 | Ujpest Dozsa - Sociedad 1-1 | | | | 01.10.1980 | Sociedad - Ujpest Dozsa 1-0 | |
|   AZ Alkmaar til 2. runde | |
| | 17.09.1980 | AZ Alkmaar - Red Boys Differdange 6-0 | | | | 30.09.1980 | Red Boys Differdange - AZ Alkmaar 0-4 | |
|  FC Utrecht til 2. runde | |
| | 17.09.1980 | Arges Pitesti - FC Utrecht 0-0 | | | | 01.10.1980 | FC Utrecht - Arges Pitesti 2-0 | |
|   Vorwärts Frankfurt til 2. runde | |
| | 17.09.1980 | Ballymena - Vorwärts Frankfurt 2-1 | | | | 01.10.1980 | Vorwärts Frankfurt - Ballymena 3-0 | |
|  Bohemians Prag til 2. runde | |
| | 17.09.1980 | Bohemians Prag - Sporting Gijon 3-1 | | | | 01.10.1980 | Sporting Gijon - Bohemians Prag 2-1 | |
|  Dynamo Dresden til 2. runde | |
| | 17.09.1980 | Dynamo Dresden - Napredak 1-0 | | | | 01.10.1980 | Napredak - Dynamo Dresden 0-1 | |
|   St. Mirren til 2. runde | |
| | 17.09.1980 | Elfsborg - St. Mirren 1-2 | | | | 01.10.1980 | St. Mirren - Elfsborg 0-0 | |
| Hamburger SV til 2. runde | |
| | 17.09.1980 | Hamburger SV - Sarajevo 4-2 | | | | 01.10.1980 | Sarajevo - Hamburger SV 3-3 | |
|   Ipswich til 2. runde | |
| | 17.09.1980 | Ipswich - Aris Saloniki 5-1 | | | | 01.10.1980 | Aris Saloniki - Ipswich 3-1 | |
|  Juventus til 2. runde | |
| | 17.09.1980 | Juventus - Panathinaikos 4-0 | | | | 01.10.1980 | Panathinaikos - Juventus 4-2 | |
|  Kaiserslautern til 2. runde | |
| | 17.09.1980 | Kaiserslautern - Anderlecht 1-0 | | | | 01.10.1980 | Anderlecht - Kaiserslautern 3-2 | |
|   Levski-spartak Sofia til 2. runde | |
| | 17.09.1980 | Dinamo Kiev - Levski-Spartak Sofia 1-1 | | | | 01.10.1980 | Levski-Spartak Sofia - Dinamo Kiev 0-0 | |
| PSV Eindhoven til 2. runde | |
| | 17.09.1980 | PSV Eindhoven - Wolverhampton 3-1 | | | | 01.10.1980 | Wolverhampton - PSV Eindhoven 1-0 | |
|   St. Etienne til 2. runde | |
| | 17.09.1980 | PS Kuopio - St. Etienne 0-7 | | | | 01.10.1980 | St. Etienne - PS Kuopio 7-0 | |
|  Radnicki Nis til 2. runde | |
| | 17.09.1980 | LASK Linz - Radnicki Nis 1-2 | | | | 01.10.1980 | Radnicki Nis - LASK Linz 4-1 | |
| Lokeren til 2. runde | |
| | 17.09.1980 | Lokeren - Dinamo Moskva 1-1 | | | | 01.10.1980 | Dinamo Moskva - Lokeren 0-1 | |
|  FC Magdeburg til 2. runde | |
| | 17.09.1980 | FC Magdeburg - Moss 2-1 | | | | 01.10.1980 | Moss - FC Magdeburg 2-3 | |
|  Widzew Lodz til 2. runde | |
| | 17.09.1980 | Manchester United - Widzew Lodz 1-1 | | | | 01.10.1980 | Widzew Lodz - Manchester United 0-0 | |
|   FC Porto til 2. runde | |
| | 17.09.1980 | FC Porto - Dundalk 1-0 | | | | 01.10.1980 | Dundalk - FC Porto 0-0 | |
| Torino til 2. runde | |
| | 17.09.1980 | RWD Molenbeek - Torino 1-2 | | | | 01.10.1980 | Torino - RWD Molenbeek 2-2 | |
| Frankfurt til 2. runde | |
| | 17.09.1980 | Shakhtar Donetsk - Frankfurt 1-0 | | | | 01.10.1980 | Frankfurt - Shakhtar Donetsk 3-0 | |
| Dundee United til 2. runde | |
| | 17.09.1980 | Slask Wroclaw - Dundee United 0-0 | | | | 01.10.1980 | Dundee United - Slask Wroclaw 7-2 | |
| Sochaux til 2. runde | |
| | 17.09.1980 | Sochaux - Servette 2-0 | | | | 01.10.1980 | Servette - Sochaux 2-1 | |
| Standard Liége til 2. runde | |
| | 17.09.1980 | Standard Liège - Steaua Bukarest 1-1 | | | | 01.10.1980 | Steaua Bukarest - Standard Liège 1-2 | |
|  Stuttgart til 2. runde | |
| | 17.09.1980 | Stuttgart - Pezoporikos 6-0 | | | | 24.09.1980 | Pezoporikos - Stuttgart 1-4 | |
| Twente til 2. runde | |
| | 17.09.1980 | Twente - IFK Göteborg 5-1 | | | | 01.10.1980 | IFK Göteborg - Twente 2-0 | |
| Boavista til 2. runde | |
| | 17.09.1980 | Vasas Budapest - Boavista 0-2 | | | | 01.10.1980 | Boavista - Vasas Budapest 0-1 | |
| Zbrojovka Brno til 2. runde | |
| | 17.09.1980 | Zbrojovka Brno - Vöest Linz 3-1 | | | | 01.10.1980 | Vöest Linz - Zbrojovka Brno 0-2 | |
|  Beroe Stara Zagora til 2. runde | |
| | 17.09.1980 | Fenerbahce - Beroe Stara Zagora 0-1 | | | | 01.10.1980 | Beroe Stara Zagora - Fenerbahce 2-1 | |
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Forside