| Bodø Glimt til 4. kvalifikationsrunde mester |
|
| 05.08.2021 | FC Prishtina (kos) - Bodø/Glimt (nor) 2-1 | | 12.08.2021 | Bodø/Glimt (nor) - FC Prishtina (kos) 2-0 | |
| 11. | 0-1 | Patrick Berg | | 18. | 1-0 | Erik Botheim |
| 44. | 1-1 | John Oto John | | 78. | 2-0 | Erik Botheim |
| 82. | 2-1 | Selvmål, Marius Lode | | | | |
|
| Fola Esch til 4. kvalifikationsrunde mester |
|
| 03.08.2021 | Linfield (nir) - Fola Esch (lux) 1-2 | | 12.08.2021 | Fola Esch (lux) - Linfield (nir) 2-1 | |
| 9. | 1-0 | Billy Chadwick | | 69. | 1-0 | Bruno Correia |
| 69. | 1-1 | Stefano Bensi | | 90. | 1-1 | Sam Roscoe-Byrne |
| 89. | 1-2 | Gauthier Caron | | 90. | 2-1 | Rodrigo Parreira, straffe | |
|
| Riga FC til 4. kvalifikationsrunde mester |
|
| 05.08.2021 | Riga FC (let) - Hibernians (mal) 0-1 | | 12.08.2021 | Hibernians (mal) - Riga FC (let) 1-4 | |
| 70. | 0-1 | Andrei Agius | | 49. | 0-1 | Jean-Baptiste Leo |
| | | | | 60. | 1-1 | Jurgen Degabriele |
| | | | | 90. |  | Jake Grech. Hibernians |
| | | | | 90. | 1-2 | Ivan Paurevic |
| | | | | 105. | 1-3 | Yunusa Muritala |
| | | | | 111. |  | Vladimirs Kamess, Riga FC |
| | | | | 115. | 1-4 | Yunusa Muritala |
|
| Shamrock Rovers til 4. kvalifikationsrunde mester |
|
| 05.08.2021 | Shamrock Rovers (irl) - Teuta Durres (alb) 1-0 | | 12.08.2021 | Teuta Durres (alb) - Shamrock Rovers (irl) 0-2 | |
| 90. | 1-0 | Aidomo Emakhu | | | | |
|
| Maccabi Haifa til 4. kvalifikationsrunde mester |
|
| 05.08.2021 | Maccabi Haifa (isr) - HB (fær) 7-2 | | 12.08.2021 | HB (fær) - Maccabi Haifa (isr) 1-0 | |
| 6. | 1-0 | Din David | | 20. | 1-0 | Michal Przybylski |
| 24. | 2-0 | Din David | | | |
| 29. | 2-1 | Mikkel Dahl ' | | | |
| 45. | 3-1 | Dolev Haziza | | | |
| 60. | | Hedin Hansen, HB | | | |
| 62. | 4-1 | Ramon Gershon | | | |
| 70. | 4-2 | Daniel Johansen, straffe | | | |
| 74. | 5-2 | Ben Sahar | | | |
| 82. | 6-2 | Omer Atzili | | | |
| 90. | 7-2 | Yuval Ashkenazi | | | | |
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Forside