| Feyenoord til semifinaler |
|
| 07.04.2022 | Feyenoord - Slavia Prag 3-3 | | 14.04.2022 | Slavia Prag - Feyenoord 1-3 | |
| 10. | 1-0 | Luis Sinisterra | | 2. | 0-1 | Cyriel Dessers |
| 41. | 1-1 | Peter Olayinka | | 14. | 1-1 | Ibrahim Traore |
| 67. | 1-2 | Collins Sor | | 59. | 1-2 | Cyriel Dessers |
| 74. | 2-2 | Marcos Senesi | | 78. | 1-3 | Luis Sinisterra |
| 86. | 3-2 | Orkun Kökcü | | 90. |  | Taras Kacharaba, Slavia Prag |
| 90. | 3-3 | Ibrahim Traore | | | | |
|
|
| 07.04.2022 | Bodø/Glimt - Roma 2-1 | | 14.04.2022 | Roma - Bodø/Glimt 4-0 | |
| 43. | 0-1 | Lorenzo Pellegrini | | 5. | 1-0 | Tammy Abraham |
| 56. | 1-1 | Ulrik Saltnes | | 23. | 2-0 | Nicolo Zaniolo |
| 89. | 2-1 | Hugo Vetlesen | | 29. | 3-0 | Nicolo Zaniolo |
| | | | | 49. | 4-0 | Nicolo Zaniolo |
|
| Marseille til semifinaler |
|
| 07.04.2022 | Marseille - PAOK Saloniki 2-1 | | 14.04.2022 | PAOK Saloniki - Marseille 0-1 | |
| 13. | 1-0 | Gerson | | 34. | 0-1 | Dimitri Payet |
| 45. | 2-0 | Dimitri Payet | | | |
| 48. | 2-1 | Omar El Kaddouri | | | |
| 90. |  | Gerson, Marseille | | | | |
|
| Leicester til semifinaler |
|
| 07.04.2022 | Leicester - PSV Eindhoven 0-0 | | 14.04.2022 | PSV Eindhoven - Leicester 1-2 | |
| | | | | 27. | 1-0 | Eran Zahavi |
| | | | | 77. | 1-1 | James Maddison |
| | | | | 88. | 1-2 | Ricardo Pereira |
|
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Forside
