| PSV Eindhoven til kvartfinaler |
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| 10.03.2022 | PSV Eindhoven - FC København  4-4 | | 17.03.2022 | FC København - PSV Eindhoven 0-4 | |
| 6. | 0-1 | Isak Johannesson | | 10. | 0-1 | Eran Zahavi |
| 21. | 1-1 | Cody Gakpo | | 38. | 0-2 | Mario Götze |
| 23. | 1-2 | Pep Biel | | 79. | 0-3 | Eran Zahavi |
| 43. | 1-3 | Lukas Lerager | | 90. | 0-4 | Noni Madueke |
| 50. | 2-2 | Ritsu Doan | | | |
| 70. | 3-3 | Cody Gakpo | | | |
| 78. | 3-4 | Pep Biel | | | |
| 85. | 4-4 | Eran Zahavi | | | | |
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| Marseille til kvartfinaler |
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| 10.03.2022 | Marseille - FC Basel 2-1 | | 17.03.2022 | FC Basel - Marseille 1-2 | |
| 19. | 1-0 | Arkadiusz Milik | | 63. | 1-0 | Dan Ndoye |
| 68. | 2-0 | Arkadiusz Milik | | 74. | 1-1 | Cengiz Ünder |
| 80. | 2-1 | Sebastiano Esposito | | 90. | 1-2 | Valentin Rongier | |
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| PAOK Saloniki til kvartfinaler |
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| 10.03.2022 | PAOK Saloniki - Gent 1-0 | | 17.03.2022 | Gent - PAOK Saloniki 1-2 | |
| 58. | 1-0 | Jasmin Kurtic | | 20. | 0-1 | Jose Angel Crespo |
| | | | | 40. | 1-1 | Laurent Depoitre |
| | | | | 77. | 1-2 | Douglas Augusto |
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| 10.03.2022 | Vitesse - Roma 0-1 | | 17.03.2022 | Roma - Vitesse 1-1 | |
| 45. | 0-1 | Sérgio Oliveira | | 62. | 0-1 | Maximilian Wittek |
| 78. |  | Sérgio Oliveira, Roma | | 90. | 1-1 | Tammy Abraham | |
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| Slavia Prag til kvartfinaler |
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| 10.03.2022 | Slavia Prag - LASK Linz 4-1 | | 17.03.2022 | LASK Linz - Slavia Prag 4-3 | |
| 3. | 1-0 | Collins Sor | | 24. | 0-1 | Peter Olayinka |
| 29. | 2-0 | Collins Sor | | 36. | 1-1 | Philipp Wiesinger |
| 67. | 2-1 | Husein Balic | | 37. | 1-2 | Alexander Bah |
| 83. | 3-1 | Peter Olayinka | | 42. | | Aiham Ousou, Slavia Prag |
| 85. | 4-1 | Ibrahim Traore | | 62. | 1-3 | Collins Sor |
| | | | | 76. | 2-3 | Philipp Wiesinger |
| | | | | 85. |  | Srdjan Plavsic, Slavia Prag |
| | | | | 87. | 3-3 | Andreas Gruber |
| | | | | 89. | 4-3 | Alexander Schmidt | |
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| Feyenoord til kvartfinaler |
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| 10.03.2022 | Partizan Beograd - Feyenoord 2-5 | | 17.03.2022 | Feyenoord - Partizan Beograd 3-1 | |
| 13. | 1-0 | Bebras Natcho | | 45. | 1-0 | Cyriel Dessers |
| 20. | 1-1 | Jens Toornstra | | 59. | 2-0 | Reiss Nelson |
| 46. | 2-1 | Nemanja Jovic | | 61. | 2-1 | Ricardo Gomes |
| 52. | 2-2 | Cyriel Dessers | | 90. | 3-1 | Bryan Linssen |
| 64. | 2-3 | Lutsharel Geertruida | | | |
| 71. | 2-4 | Luis Sinisterra | | | |
| 77. | 2-5 | Jens Toornstra | | | | |
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| Leicester til kvartfinaler |
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| 10.03.2022 | Leicester - Rennes 2-0 | | 17.03.2022 | Rennes - Leicester 2-1 | |
| 30. | 1-0 | Marc Albrighton | | 8. | 1-0 | Benjamin Bourigeaud |
| 90. | 2-0 | Kelechi Iheanacho | | 51. | 1-1 | Wesley Fofana |
| | | | | 76. | 2-1 | Flavien Tait | |
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| Bodø/Glimt til kvartfinaler |
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| 10.03.2022 | Bodø/Glimt - AZ Alkmaar 2 - 1 | | 17.03.2022 | AZ Alkmaar - Bodø/Glimt 2-2 | |
| 39. | 1-0 | Amahl Pellegrino | | 18. | 1-0 | Evangelos Pavlidis |
| 73. | 1-1 | Zakaria Aboukhlal | | 26. | 1-1 | Amahl Pellegrino |
| 90. | 2-1 | Ola Solbakken, straffe | | 30. | 2-1 | Evangelos Pavlidis |
| | | | | 105. | 2-2 | Alfons Sampsted | |
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Forside