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| 1 | Fernando Muslera |  Galatasaray | 16.06.1986 | |
| 12 | Sebastian Sosa |  Independiente | 19.08.1986 | |
| 23 | Sergio Rochet |  Nacional | 23.03.1993 | |
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| 2 | José Giménez |  Atletico Madrid | 20.01.1995 | |
| 3 | Diego Godin | Vélez Sarsfield | 16.02.1986 | |
| 4 | Ronald Araujo | FC Barcelona | 07.03.1999 | |
| 13 | Guillermo Varela |  Flamengo | 24.03.1993 | |
| 16 | Mathias Olivera |  Napoli | 31.10.1997 | |
| 17 | Matias Vina | Roma | 09.11.1997 | |
| 19 | Sebastian Coates |  Sporting CP | 07.10.1990 | |
| 22 | Martin Caceres |  LA Galaxy | 07.04.1987 | |
| 26 | José Luis Rodriguez | Nacional | 14.03.1997 | |
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| 5 | Matias Vecino | Lazio | 24.08.1991 | |
| 6 | Rodrigo Bentancur |  Tottenham | 25.06.1997 | |
| 7 | Nicolas de la Cruz | River Plate | 01.06.1997 | |
| 10 | Giorgian de Arrascaeta | Flamengo | 01.06.1994 | |
| 14 | Lucas Torreira | Galatasaray | 11.02.1996 | |
| 15 | Federico Valverde | Real Madrid | 22.07.1998 | |
| 24 | Agustin Canobbio | Athletico Paranaense | 01.10.1998 | |
| 25 | Manuel Ugarte | Sporting CP | 11.04.2001 | |
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| 8 | Facundo Pellistri | Manchester United | 20.12.2001 | |
| 9 | Luis Suarez | Nacional | 24.01.1987 | |
| 11 | Darwin Nunez | Liverpool | 24.06.1999 | |
| 18 | Maxi Gomez | Trabzonspor | 14.08.1996 | |
| 20 | Facundo Torres | Orlando City SC | 13.04.2000 | |
| 21 | Edinson Cavani | Valencia | 14.02.1987 | |
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